Evidence map›Paper›PMID 42305610›Full record

ArticleiScience2026

Ion transport peptide regulates larval body water balance via a receptor guanylyl cyclase in

Akira Watanabe, Takashi Koyama, Olga Kubrak, Michael James Texada, Megumi Furumitsu, Eiko Iwakoshi-Ukena, Roilea Maxson, Taishi Yoshii, Shu Kondo, Naoki Yamanaka and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Akira WatanabeDegree Programs in Life and Earth Sciences, Graduate School of Science and Technology, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8572, Japan.
Takashi KoyamaDepartment of Biology, Section for Cell and Neurobiology, University of Copenhagen, Universitetsparken 15, Building 3, Copenhagen 2100, Denmark.
Olga KubrakDepartment of Biology, Section for Cell and Neurobiology, University of Copenhagen, Universitetsparken 15, Building 3, Copenhagen 2100, Denmark.
Michael James TexadaDepartment of Biology, Section for Cell and Neurobiology, University of Copenhagen, Universitetsparken 15, Building 3, Copenhagen 2100, Denmark.
Megumi FurumitsuGraduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-8521, Japan.
Eiko Iwakoshi-UkenaGraduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-8521, Japan.
Roilea MaxsonDepartment of Entomology, Institute for Integrative Genome Biology, University of California, Riverside, 900 University Ave, Riverside, CA 92521, USA.
Taishi YoshiiGraduate School of Environmental, Life, Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
Shu KondoDepartment of Biological Science and Technology, Faculty of Advanced Engineering, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan.
Naoki YamanakaDepartment of Entomology, Institute for Integrative Genome Biology, University of California, Riverside, 900 University Ave, Riverside, CA 92521, USA.
Kazuyoshi UkenaGraduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima 739-8521, Japan.
Kim RewitzDepartment of Biology, Section for Cell and Neurobiology, University of Copenhagen, Universitetsparken 15, Building 3, Copenhagen 2100, Denmark.
Ryusuke NiwaLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8577, Japan.
Naoki OkamotoLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8577, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maintaining internal water balance, including ionic and osmotic homeostasis, is critical for animal development and survival. Water balance is controlled by multiple hormones, but the underlying endocrine mechanisms remain largely unknown. Here, we show that the short amidated isoform of ion transport peptide (saITP), secreted from brain neurosecretory cells, regulates larval body water balance via the receptor guanylyl cyclase (rGC) Gyc76C in the hindgut of the fruit fly

Indexed as

Animal physiologyCell biologyDevelopmental biology

Identifiers

PMID42305610
PMCPMC13267572

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.