Evidence map›Paper›PMID 42305601›Full record

ReviewiScience2026

Optical mapping: pioneering the frontier of preclinical antiarrhythmic drug evaluation.

Yangpeng Li, Yuqing Zheng, Ruirui Dong, Miao Lin, Tangting Chen, Jianhong Li, Rui Zhang, Ting Liu, Xiaoqiu Tan, Guoliang Hao and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yangpeng LiDepartment of Cardiac Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830017, China.
Yuqing ZhengKey Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China.
Ruirui DongHenan Academy of Innovations in Medical Science, Zhengzhou 450000, China.
Miao LinKey Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China.
Tangting ChenKey Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China.
Jianhong LiKey Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China.
Rui ZhangKey Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China.
Ting LiuKey Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China.
Xiaoqiu TanKey Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China.
Guoliang HaoHenan Academy of Innovations in Medical Science, Zhengzhou 450000, China.
Xianhong OuKey Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Department of Cardiology of the Affiliated Hospital, Southwest Medical University, Luzhou 646000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Optical mapping has emerged as a unique technique in cardiac electrophysiology since its emergence in the 1970s. By acquiring high spatiotemporal resolution optical datasets using fluorescent dyes, this technique propels the progress of cardiac electrophysiology and the development of antiarrhythmic drug evaluation. This review outlines its application in drug evaluation, including the fundamental principles, major advantages, multiple electrophysiological parameters, and combination with other techniques for predicting proarrhythmic risk and identification of antiarrhythmic drugs. An overview of the drugs tested via the optical mapping method is presented, showcasing its extensive practical utility. This review provides a comprehensive framework for the analysis of arrhythmia mechanisms and drug development using optical mapping. Finally, its limitations and prospects of optical mapping in deciphering the arrhythmogenic mechanism and evaluating antiarrhythmic drugs are discussed, providing references for promoting its clinical translation.

Indexed as

biophysicsmedicineoptical imaging

Identifiers

PMID42305601
PMCPMC13267561

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.