Evidence map›Paper›PMID 42305591›Full record

ArticleiScience2026

Impaired sleep resilience underlies transient neural instability in insomnia disorder.

Chao Yang, Hai Gu, He Chen, Guohua Chen, Xinhua Song, Xin Liu, Qing Yang, Guang Wang, Cancheng Li, Heng Gu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Chao YangState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern, Beijing Normal University, Beijing 100875, China.
Hai GuState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern, Beijing Normal University, Beijing 100875, China.
He ChenSchool of Automation Science and Engineering, South China University of Technology, Guangzhou 511442, China.
Guohua ChenDepartment of Neurology, Wuhan First Hospital, Wuhan 430022, China.
Xinhua SongClinical College of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Wuhan 430065, China.
Xin LiuDepartment of Neurology, Wuhan First Hospital, Wuhan 430022, China.
Qing YangDepartment of Neurology, Wuhan First Hospital, Wuhan 430022, China.
Guang WangClinical College of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Wuhan 430065, China.
Cancheng LiSchool of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
Heng GuNingbo Institute of Dalian University of Technology, Ningbo 315014, China.
Shaodi WangDepartment of Anesthesiology, Peking University Third Hospital, Beijing 100191, China.
Peiyang GuoState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern, Beijing Normal University, Beijing 100875, China.
Jiawei ZhaoState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern, Beijing Normal University, Beijing 100875, China.
Lu WangState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern, Beijing Normal University, Beijing 100875, China.
Rui WangState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern, Beijing Normal University, Beijing 100875, China.
Changming WangBeijing Luhe Hospital, Capital Medical University, Beijing 101149, China.
Junhua MeiDepartment of Neurology, Wuhan First Hospital, Wuhan 430022, China.
Xiaoli LiState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern, Beijing Normal University, Beijing 100875, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study quantified sleep resilience in insomnia disorder (ID) by examining the brain's ability to resist, contain, and recover from auditory perturbations during nocturnal sleep. 58 ID patients and 43 healthy controls underwent real-time staged nocturnal recordings with event-locked auditory stimulation. Neural responses were evaluated using evoked complexity, P300, event-related phase-amplitude coupling (ERPAC), and coupling pattern diversity. Compared with controls, ID patients showed elevated evoked complexity and enlarged P300 responses, especially in N3 sleep, indicating reduced resistance to disturbance. ID patients also exhibited stronger fronto-parietal ERPAC during the middle post-stimulus window, suggesting impaired containment. These abnormalities weakened in the late window, consistent with relatively preserved recovery. In conclusion, ID is marked by impaired sleep resilience, particularly in deep sleep, and sleep resilience may provide useful objective markers of nocturnal instability.

Indexed as

Health sciencesMedicineNeurology

Identifiers

PMID42305591
PMCPMC13266136

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.