ArticleiScience2026
BCL6 in T cells promotes type 1 diabetes by redirecting fates of insulin-autoreactive B lymphocytes.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Currently approved immunotherapies for type 1 diabetes (T1D) broadly target T cells and delay, but do not fully prevent, diabetes development, highlighting the need for more selective targets. Here, we show that T cell loss of the key germinal center protein, BCL6 prevents diabetes, despite the continued presence of anti-insulin B cells. This protection was associated with reduced anti-insulin B cell activation and proliferation. ΔBCL6 adoptively transferred CD4
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