ReviewBone reports2026
Fibrin, from blood to bone: a review.
Review in Bone reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibrin is principally involved in blood coagulation and hemostasis. Its structure, abundance and turnover are reciprocally related to blood flow. Decreased abundance of fibrin in afibrinogenemic or hemophilic patients leads to bone disorders such as bone cysts or hemarthroses. Fibrin accumulation in growing children with chronic disease leads to osteoarthritis and physeal disruption. Despite its clear role in bone disorders; the underlying mechanisms are not clearly understood. Bone formation and hemostasis is mediated by osteocyte mechanosensitivity involving plasma membrane disruption, calcium signaling cascade. Fibrin is related to mechanotransduction in platelets and recently in mitochondrial mechanosensing in macrophages, however its role in bone mechanobiology is not elucidated. This review underlines the link of fibrin and bone pathophysiology and emphasizes the gap of knowledge between fibrin function during healing and mechanobiology of bone homeostasis. This review proposed an original perspective to better understand bone loss, repair and formation, that could open the path to further investigations to adapt innovative therapeutic strategies.
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