Evidence map›Paper›PMID 42305461›Full record

ArticleTranslational cancer research2026

Carcinogenic role of ESCO2 in cholangiocarcinoma: integration of bioinformatics analysis and experimental validation.

Le Fan, Yong Jiang, Jing Hu, Feng Xiao, Yunxia Chai, Bin Yi, Yinghe Qiu

Abstract read
In one paragraph

Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Le Fan *Department of Organ Transplantation, the Third Affiliated Hospital of Naval Medical University (Oriental Hepatobiliary Surgery Hospital), Shanghai, China.ORCID https://orcid.org/0009-0009-8829-3904
Yong Jiang *Department of Organ Transplantation, the Third Affiliated Hospital of Naval Medical University (Oriental Hepatobiliary Surgery Hospital), Shanghai, China.ORCID https://orcid.org/0009-0004-5462-5310
Jing HuDepartment of Medical Imaging, Shanghai Yangpu District Shidong Hospital, Shanghai, China.ORCID https://orcid.org/0009-0003-9354-9157
Feng XiaoDepartment of Organ Transplantation, the Third Affiliated Hospital of Naval Medical University (Oriental Hepatobiliary Surgery Hospital), Shanghai, China.ORCID https://orcid.org/0009-0002-0051-1794
Yunxia ChaiDepartment of Organ Transplantation, the Third Affiliated Hospital of Naval Medical University (Oriental Hepatobiliary Surgery Hospital), Shanghai, China.ORCID https://orcid.org/0009-0000-0652-7143
Bin YiDepartment of Organ Transplantation, the Third Affiliated Hospital of Naval Medical University (Oriental Hepatobiliary Surgery Hospital), Shanghai, China.ORCID https://orcid.org/0009-0001-6347-222X
Yinghe QiuDepartment of Organ Transplantation, the Third Affiliated Hospital of Naval Medical University (Oriental Hepatobiliary Surgery Hospital), Shanghai, China.ORCID https://orcid.org/0009-0005-3309-0705

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cholangiocarcinoma (CCA) is a highly heterogeneous biliary malignancy with a poor prognosis. Finding early diagnosis and therapeutic targets for CCA is of great importance. The aim of this study was to screen for key genes involved in CCA using bioinformatics analysis, identify establishment of sister chromatid cohesion N-acetyltransferase 2 ( Methods: The CCA data were downloaded using the Gene Expression Comprehensive Database and the Cancer Genome Atlas, the core gene Results: A total of 1,372 differential genes were screened in this study, with 742 up-regulated genes including Conclusions:

Indexed as

bioinformaticsCholangiocarcinoma (CCA)establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2)prognosisproliferation

Identifiers

PMID42305461
PMCPMC13265162

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.