ArticleJournal of surgical case reports2026
IgG4-related disease presenting as a gastric mass necessitating total gastrectomy: a case report.
Article in Journal of surgical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
IgG4-related disease (IgG4-RD) is a multi-system disorder that rarely presents with gastric manifestations. A 26 year old woman presented with post-prandial symptoms of dyspepsia, dysphagia and reflux with a proximal submucosal gastric mass on imaging and endoscopy. She underwent a number of endoscopic and laparoscopic biopsies, which were inconclusive. Suspecting IgG4-RD, steroids were trialled empirically, but did not result in radiological or symptom improvement. Ultimately, she underwent a total gastrectomy, D2 lymphadenectomy and Roux-en-Y oesophago-jejunostomy. On final histopathological analysis of this resection, the diagnosis of gastric IgG4-RD was favoured. Most reports of resection for IgG4-RD in the stomach suggest that it can be treated medically if the level of clinical suspicion is sufficiently high. However, in this case despite clinical suspicion, the initial biopsies were non-diagnostic and empirical steroids failed, demonstrating that these approaches do not always allow avoidance of major surgery for diagnosis and treatment.
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