ArticleArchives of medical science : AMS2026
HER2-low status in breast cancer: clinicopathological factors and prognostic value.
Article in Archives of medical science : AMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Introduction: This study aimed to assess the prognostic importance of HER2-low status in breast cancer (BC). Additionally, we compared the HER2-low subgroup (defined as HER2-low1+; HER2-low2+/ISH(-)) with HER2-zero and HER2-positive subgroups according to clinical, histopathological, and molecular characteristics. Material and methods: The study analyzed the medical records of BC patients treated at the National Institute of Oncology in Gliwice, Poland, between 2002 and 2018. HER2 overexpression was assessed in postoperative specimens or samples obtained via core needle biopsy. Results: Of the 657 tumors, 176 (27%) tumors were classified as HER2-low BC, 248 (38%) as HER2-zero and 233 (35%) as HER2-positive tumors. BC patients with HER2-low tumors were more likely to have hormone receptor-positive (HR+) status compared to those with HER2-zero tumors (82.4% vs. 62.1%, Conclusions: HER2-low status was associated with worse OS in breast cancer patients with certain negative prognostic factors compared with HER2-zero status. Additionally, HER2-low1+ and HER2-low2+/ISH(-) subgroups predominantly exhibited HR+ status.
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