Evidence map›Paper›PMID 42305329›Full record

ArticleArchives of medical science : AMS2026

Interplay between parathyroid hormone concentration and valvular and aortic calcifications.

Anna Olasińska-Wiśniewska, Kajetan Grodecki, Karolina Jemielity, Tomasz Urbanowicz, Marcin Misterski, Marek Grygier, Piotr Kübler, Bartłomiej Perek, Marcin Protasiewicz, Damini Dey and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of medical science : AMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anna Olasińska-WiśniewskaDepartment of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland.
Kajetan GrodeckiFirst Department of Cardiology, Medical University of Warsaw, Poland.
Karolina JemielityDepartment of Radiology, Poznań University of Medical Sciences, Poznan, Poland.
Tomasz UrbanowiczDepartment of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland.
Marcin MisterskiDepartment of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland.
Marek GrygierFirst Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland.
Piotr KüblerInstitute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
Bartłomiej PerekDepartment of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland.
Marcin ProtasiewiczInstitute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
Damini DeyDepartment of Biomedical Sciences, and Department of Medicine, Cedars-Sinai Medical Center, Biomedical Imaging Research Institute, Los Angeles, CA, USA.
Marek JemielityDepartment of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, Poznan, Poland.

Funding

Integrated prediction of cardiovascular events by automated coronary plaque and pericoronary adipose tissue quantification from CT AngiographyR01HL148787 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI DEY, DAMINI · 2020 to 2023
$3.0M
AI-enabled characterization of fibrocalcific aortic valve disease and inflammation from CT Angiography: Patient-specific outcome predictionR01HL175875 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Damini Dey · 2024 to 2026
$2.4M
Effect of Intensive Medical Treatment on Quantified Coronary Artery Plaque Components with Serial Coronary CTA in Women with Non-Obstructive CADR01HL151266 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI DEY, DAMINI, TAMARAPPOO, BALAJI K. · 2020 to 2023
$1.6M
NHLBI NIH HHS R01 HL148787NHLBI NIH HHS R01 HL151266NHLBI NIH HHS R01 HL175875
6 · The paper itself

Abstract

Introduction: Recently, a relationship between hyperparathyroidism and cardiovascular disorders has been highlighted. The current study aimed to identify a potential relationship between parathyroid hormone (PTH) and valvular calcification performance. A secondary aim was to evaluate the potential association between PTH concentration and post-procedural outcomes after transcatheter aortic valve implantation (TAVI). Material and methods: Patients with severe symptomatic aortic stenosis were evaluated for study eligibility. Demographics, clinical data, and blood samples were collected. Pre-procedurally, echocardiography and computed tomography (CT) were performed. Quantitative evaluation of calcific tissue was conducted over the three regions of interest - ascending aorta, aortic and mitral valves - using semiautomated software. Results: The final study group comprised 89 patients (50 females, median (Q1-3) age of 77 (72-82) years. Increased PTH concentration was associated with a higher peak aortic gradient ( Conclusions: Increased PTH concentration is associated with calcific tissue attenuation but not calcium volume, suggesting that PTH may influence the degree of calcium accumulation in degenerated regions. PTH could potentially serve as a biomarker of calcific loading in valvular heart disease. However, PTH concentration does not appear to be associated with the rate of complications following TAVI.

Indexed as

aortic stenosiscalcificationcomputed tomographyparathyroid hormone

Identifiers

PMID42305329
PMCPMC13266536

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.