Evidence map›Paper›PMID 42305321›Full record

ArticleArchives of medical science : AMS2026

ADCY2, ADCY5, and GRIA1 as key genes of the cAMP signaling pathway in osteoporotic spinal fracture after manipulation of Wnt signaling.

Xiaohua Zuo, Changdong Zhou, Xuepiao Zhu, Dan Liu, Yan Wang, Hongguang Bao, Kai Zhang, Yong Zhang

Abstract read
In one paragraph

Article in Archives of medical science : AMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaohua ZuoDepartment of Anesthesiology, The Affiliated Nanjing Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Changdong ZhouDepartment of Image, The Affiliated Huai'an Hospital of Xuzhou Medical University and The Second People's Hospital of Huai'an, Huai'an, Jiangsu, China.
Xuepiao ZhuDepartment of Pain Management, The Affiliated Huai'an Hospital of Xuzhou Medical University and The Second People's Hospital of Huai'an, Huai'an, Jiangsu, China.
Dan LiuDepartment of Image, The Affiliated Huai'an Hospital of Xuzhou Medical University and The Second People's Hospital of Huai'an, Huai'an, Jiangsu, China.
Yan WangDepartment of Medicine Laboratory, The Second People's Hospital of Lianyungang, Lianyungang, Jiangsu, China.
Hongguang BaoDepartment of Anesthesiology, The Affiliated Nanjing Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Kai ZhangDepartment of Medicine Laboratory, The Affiliated Huai'an Hospital of Xuzhou Medical University and The Second People's Hospital of Huai'an, Huai'an, Jiangsu, China.
Yong ZhangDepartment of Endocrinology, The Affiliated Huai'an Hospital of Xuzhou Medical University and The Second People's Hospital of Huai'an, Huai'an, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Osteoporotic spinal fracture, characterized by high morbidity and mortality, has become a health burden for the aging population. Inactivation of the Wnt signaling has been proved to promote osteoporotic fractures. Our study aimed to identify key genes, miRNAs, and pathways that possibly lead to osteoporosis and osteoporotic spinal fracture after aberrant activation or mutation of the Wnt signaling pathway. Material and methods: The Results: 562 DEGs were screened out using the Conclusions: The results demonstrated that ADCY2, ADCY5, and GRIA1 are key genes regulating the cAMP signaling pathway in osteoporotic spinal fracture after abnormal Wnt signaling.

Indexed as

cAMP signalingGRIA1spinal fractureWnt signaling pathway

Identifiers

PMID42305321
PMCPMC13266740

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.