ArticleArchives of medical science : AMS2026
miR-93-5p attenuates apoptosis and autophagy by regulating SRY-box2 in spinal cord-injured rats
Article in Archives of medical science : AMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: In the current work we studied the involvement of miR-93-5p in spinal cord injury (SCI) by involving SCI rats and LPS-mediated injuries in PC12 cells. Material and methods: The PC12 cells were exposed to LPS in order to induce cell injury that mimicked the Results: The treatment of LPS caused cell injuries in PC12 cells. The levels of miR-93-5p were suppressed in LPS-injured cells. Over-expression of miR-93-5p decreased autophagy and apoptosis and increased cell viability in LPS injured cells via up-regulation of SRY-box2. Up-regulation of SRY-box2 ameliorated LPS-mediated cell injury whereas suppression of SRY-box2 accelerated the LPS-mediated cell injury. Also, upregulation of miR-93-5p blocked the JAK/STAT and MAPK/ERK pathways via up-regulating the expression of SRY-box2. Treatment in SCI rats with miR-93-5p agomir inhibited cell apoptosis and autophagy. Conclusions: The results of the study confirmed the attenuating role of miR-93-5p against cell autophagy and apoptosis in LPS-injured PC12 cells and SCI rats via up-regulation of the expression of SRY-box2.
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