Evidence map›Paper›PMID 42305245›Full record

ArticleNature reviews bioengineering2025

Oversimplified immunology is holding biomaterials back.

Jessica L Stelzel, Jonathan P Schneck, Hai-Quan Mao, Joshua C Doloff

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature reviews bioengineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jessica L StelzelDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jonathan P SchneckDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hai-Quan MaoDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Joshua C DoloffDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

TR&D Project 3P41EB028239 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Jordan Green, JONATHAN P SCHNECK · 2019 to 2026
$11.5M
Biostimulatory nanofiber-hydrogel composite for soft tissue remodelingR01DE031488 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI AARON W JAMES, Hai-Quan Mao · 2022 to 2026
$2.8M
Identification of cancer neoepitope-specific T cells using novel high-throughput hydrogel based platformsR33CA278429 · NCI · JOHNS HOPKINS UNIVERSITY · PI JONATHAN P SCHNECK · 2024 to 2026
$1.2M
Tolerance-Inducing mRNA Nanoparticles to Treat Type 1 DiabetesR56DK137420 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DOLOFF, JOSHUA CHARLES, GREEN, JORDAN · 2023 to 2024
$442k
Characterization and Optimization of a Nanofiber-Hydrogel Composite for Tissue RemodelingF31DE032900 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI STELZEL, JESSICA · 2023 to 2025
$98k
NCI NIH HHS R33 CA278429NIBIB NIH HHS P41 EB028239NIDCR NIH HHS F31 DE032900NIDCR NIH HHS R01 DE031488NIDDK NIH HHS R56 DK137420
6 · The paper itself

Abstract

Immune responses are complex, often defying rigid classifications. Instead of interpreting results according to reductionist categories, researchers should rely on comprehensive single-cell data to guide analysis and should remain open to unexpected immunological complexity.

Identifiers

PMID42305245
PMCPMC13268593

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.