Evidence map›Paper›PMID 42305202›Full record

ArticleACS medicinal chemistry letters2026

A SMUG1 Inhibitor Modulates the Excision of Pyrimidine DNA Damage.

Pavitra S Thacker, Yixuan Gao, Lisa McPherson, Allan Lee, April M Averill, Sumon Pratihar, Sylvie Doublié, James M Ford, Eric T Kool

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Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pavitra S ThackerDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Yixuan GaoDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.ORCID https://orcid.org/0000-0002-4495-926X
Lisa McPhersonDivision of Oncology, Stanford School of Medicine, Stanford, California 94305, United States.
Allan LeeDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
April M AverillDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont 05405, United States.
Sumon PratiharDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Sylvie DoubliéDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont 05405, United States.
James M FordDivision of Oncology, Stanford School of Medicine, Stanford, California 94305, United States.
Eric T KoolDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.

Funding

Measuring and Modulating Oxidative DNA Damage Surveillance PathwaysR01CA217809 · NCI · STANFORD UNIVERSITY · PI KOOL, ERIC T. · 2017 to 2024
$3.7M
NCI NIH HHS R01 CA217809
6 · The paper itself

Abstract

Elevated activity of DNA repair enzymes that surveil pyrimidine damage has been associated with resistance to antitumor therapies. The DNA base excision repair (BER) enzyme SMUG1 recognizes and excises a number of modified and damaged pyrimidines that arise in cellular DNA, including deoxyuridine and 5-hydroxymethyl-dU, as well as the cytotoxic antitumor pyrimidine 5-fluorodeoxyuridine (5-FdU). Here we report the discovery and development of the first SMUG1 inhibitor scaffolds, derived from a small molecule sphingosine kinase inhibitor identified as a hit in assays against the DNA repair enzyme. Partial structural optimization resulted in compound SU0617, which inhibits SMUG1 with IC

Identifiers

PMID42305202
PMCPMC13266643

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.