Evidence map›Paper›PMID 42305196›Full record

ArticleACS medicinal chemistry letters2026

Discovery of a Selective Histone Deacetylase 6 Degrader (HDAC6 PROTAC) with a Short and Rigid Linker Demonstrating Sustained Knockdown of HDAC6

Lena Ripa, Carlo Cassani, Glyn Hughes, Beatrice Ranieri, Victoria Ullah, Riccardo Zambelloni, Theresa Andreasson, Mia Collins, Botilda Lindberg, Antonio Llinas and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Lena Ripa†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.ORCID https://orcid.org/0000-0003-1533-1673
Carlo Cassani†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.
Glyn Hughes†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.
Beatrice Ranieri†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.
Victoria Ullah†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.
Riccardo Zambelloni†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.
Theresa Andreasson†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.
Mia Collins†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.ORCID https://orcid.org/0000-0001-6792-2059
Botilda Lindberg†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.
Antonio Llinas†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.ORCID https://orcid.org/0000-0003-4620-9363
Rikard Pehrson†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.
Konstantin Barylyuk†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.ORCID https://orcid.org/0000-0002-3580-0345
Julia Johansson†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.
Margareta Ek†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.ORCID https://orcid.org/0000-0001-8226-8112
Anders Gunnarsson†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.
Bomi Jung†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.
Sara Lundqvist†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.
Anna Novén†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.
Jenny Sandmark†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.
Annika Åstrand†Respiratory & Immunology, ‡Discovery Sciences, §Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183 Mölndal, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Histone deacetylase 6 (HDAC6) is a cytosolic enzyme that regulates protein acetylation and contributes to the pathogenesis of various lung diseases. We report the discovery and characterization of a novel HDAC6 degrader, compound

Identifiers

PMID42305196
PMCPMC13266647

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.