Evidence map›Paper›PMID 42305193›Full record

ArticleACS medicinal chemistry letters2026

Optimization Leading to a Potent and Selective Cbl‑b Inactive-State Inhibitor That Demonstrated

Jun Liang, Michael J Lambrecht, Malcolm P Huestis, Bingyan Zhu, Lisa M Barton, Georgette M Castanedo, Peter Man-Un Ung, Robin Larouche-Gauthier, Araz Jakalian, Jean-Philippe Leclerc and 26 more

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Jun LiangGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.ORCID https://orcid.org/0000-0002-6833-0749
Michael J LambrechtGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.ORCID https://orcid.org/0009-0008-5851-1379
Malcolm P HuestisGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Bingyan ZhuGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Lisa M BartonGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Georgette M CastanedoGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.ORCID https://orcid.org/0000-0003-4584-6715
Peter Man-Un UngGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.ORCID https://orcid.org/0000-0002-6849-5252
Robin Larouche-GauthierParaza Pharma, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada.ORCID https://orcid.org/0000-0003-1919-600X
Araz JakalianParaza Pharma, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada.
Jean-Philippe LeclercParaza Pharma, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada.
Arun YadavParaza Pharma, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada.
Pouyan HaghshenasParaza Pharma, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada.
Samuel Aubert-NicolParaza Pharma, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada.
Hossein IsmailiParaza Pharma, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada.
Liang ZhaoParaza Pharma, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada.
Melissa LeblancParaza Pharma, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada.
Hugo de AlmeidaParaza Pharma, 2525 Avenue Marie-Curie, Montreal, Quebec H4S 2E1, Canada.
Qiuyue WangWuXi AppTec Company, Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, People's Republic of China.
Thomas GarnerGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Sophia TanGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Madeleine S PrangleyGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Jodie PangGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Jeremy M MurrayGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Christine YuGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Peter L HsuGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.ORCID https://orcid.org/0000-0002-9381-6564
Sascha RutzGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Isabel IshizukaGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Haochu HuangGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Chan GaoGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Min ChenGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Liz Mutter-RottmayerGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Satoko Kakiuchi-KiyotaGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Dennis H LeungGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Ponien KouGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Linda BaoGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
Xiaojing WangGenentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the preceding work in this issue (10.1021/acsmedchemlett.6c00103), we described our initial structure-activity relationship (SAR) optimization that led to a pan-Cbl inhibitor (

Indexed as

Cancer ImmunotherapyCbl-bDruggabilityProtein−Protein InteractionRING E3 LigaseSelectivityStructure-Based Design

Identifiers

PMID42305193
PMCPMC13266484

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.