Evidence map›Paper›PMID 42305165›Full record

ArticleJTCVS structural and endovascular2025

Impact of supra-aortic vessel false lumen communications on aortic remodeling: Analysis from the PERSEVERE trial.

Kyle Eudailey, Sabin Bozso, Shinichi Fukuhara, Fernando Fleischman, Ibrahim Sultan, William Brinkman, Hiroo Takayama, Arminder Jassar, George Arnaoutakis, Michael C Moon and 1 more

Abstract read
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In one paragraph

Article in JTCVS structural and endovascular, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kyle EudaileyDivision of Cardiac Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Ala.
Sabin BozsoDivision of Cardiac Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Ala.
Shinichi FukuharaDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, Mich.
Fernando FleischmanUSC Cardiac and Vascular Institute, University of Southern California, Los Angeles, Calif.
Ibrahim SultanDivision of Cardiac Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pa.
William BrinkmanCardiac Surgery Specialists, Thoracic Aortic Clinic, The Heart Hospital Baylor Plano, Plano, Tex.
Hiroo TakayamaDivision of Cardiac, Thoracic & Vascular Surgery, Columbia University Irving Medical Center/New York Presbyterian Hospital, New York, NY.
Arminder JassarDivision of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Mass.
George ArnaoutakisDivision of Cardiovascular and Thoracic Surgery, University of Texas Austin, Austin, Tex.
Michael C MoonDivision of Cardiac Surgery, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
Wilson Y SzetoDivision of Cardiovascular Surgery, University of Pennsylvania, Philadelphia, Pa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The PERSEVERE (ProspEctive, Single ARm, Multi-center Clinical InveStigation to EValuatE the Safety and Effectiveness of AMDS in the TREatment of Acute DeBakey Type I Dissection) Trial is a US investigational device exemption study designed to evaluate the Ascyrus Medical Dissection hybrid prosthesis in the open repair of patients with acute DeBakey type I dissection with preoperative malperfusion. We sought to determine the impact of false lumen (FL) communications within the supra-aortic vessels (SAV) on aortic remodeling by analyzing total aortic diameter (TAD), FL diameter, and true lumen (TL) diameter. Methods: Ninety-three patients were enrolled from July 2022 to November 2023. Anatomic measurements were made by a core laboratory using computed tomography angiogram (CTA). For this study, analysis was limited to zones 2, 3, and 4. TAD was assessed on first postoperative CTA and at 1-year postoperatively, and growth was defined as >1.0 cm. In addition, the percent of patients with FL diameter larger than TL diameter were compared on the basis of the presence or absence of any FL communications in the SAV. Results: Fifty-five patients had a preoperative, first postoperative CTA, and 1-year CTA scan and were included in the analysis. SAV FL communications were present on preoperative computed tomography scan in 35% (19/55) and absent in 65% (36/55). In those with SAV FL communications, TAD growth occurred in 0%, 5.3%, and 21.1% in zones 2, 3, and 4, respectively. In those without SAV FL communications, TAD growth occurred in 2.8%, 2.8%, and 8.3% in zones 2, 3 and 4, respectively; the difference did not reach statistical significance. The FL was larger than TL in significantly more patients in zones 3 and 4 in those with compared with those without SAV FL communications (zone 3, 53% vs 18%; zone 4, 58% vs 18%; Conclusions: The presence of preoperative SAV FL communications has a significant impact on aortic remodeling at 1-year postoperatively. The presence of these communications is associated with a trend toward negative remodeling in zones 2, 3, and 4, in addition to a significantly larger FL compared with TL diameter, likely representing ongoing FL pressurization. Techniques to better identify SAV FL communications preoperatively may lead to a more tailored approach to operative management and more targeted postoperative surveillance in these patients.

Indexed as

acute aortic dissectionAMDS hybrid prosthesis aortic remodelingaortahemiarchmalperfusion

Identifiers

PMID42305165
PMCPMC13244690

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.