ArticleNeuro-oncology advances
Sensitivity and specificity of cerebrospinal fluid placental alkaline phosphatase in germinoma: An 8 pg/mL threshold.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cerebrospinal fluid placental alkaline phosphatase (CSF-PLAP) is useful in diagnosing intracranial germinomas. However, reports on CSF-PLAP in histological subtypes other than germinoma remain limited. The primary aim of this study was to retrospectively analyze cases with histological diagnoses in which CSF-PLAP levels were measured and evaluate the sensitivity and specificity of this test using the clinically applied cutoff value of 8 pg/mL. Methods: We retrospectively analyzed 134 patients with intracranial disease who underwent CSF-PLAP testing for diagnostic purposes and had confirmed histopathological diagnoses without receiving any adjuvant therapy before, or between CSF-PLAP measurement and surgery. The cases were categorized as true positive (TP), true negative (TN), false positive (FP), false negative, or clinical germinoma. Diagnostic accuracy was evaluated based on sensitivity, specificity, and statistical comparisons between groups. Results: Among the 134 analyzed cases, 30 were classified as TP, 99 as TN, and 5 as FP. Using the 8 pg/mL cutoff, CSF-PLAP testing demonstrated a sensitivity of 100% and a specificity of 95.2%. The mean CSF-PLAP level was significantly higher in the TP group than in the FP group, and the TP group participants were significantly younger than the FP group participants. No significant differences in CSF-PLAP levels or age were found between the TP and clinical germinoma groups, supporting their clinical equivalence. Conclusions: CSF-PLAP using an 8 pg/mL cutoff demonstrates high diagnostic accuracy for intracranial germinoma. Recognition of potential false-positive results and consideration of sampling site may further improve clinical interpretation of CSF-PLAP measurements.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.