ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2026
[Immune dynamics and predictive factors for chronic graft versus host disease following haploidentical hematopoietic stem cell transplantation in children].
Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo investigate the immunological characteristics and predictive factors of chronic graft-versus-host disease (cGVHD) in children after haploidentical allogeneic hematopoietic stem cell transplantation (Haplo-HSCT) to provide a basis for early intervention.
methodsA retrospective analysis was conducted on clinical and laboratory data of 64 children undergoing Haplo-HSCT. Peripheral blood lymphocyte subsets, immunoglobulins, and key components of the complement system were measured. Univariable and multivariable logistic regression analyses were used to identify predictors.
resultsThe percentage of helper/inducer T lymphocytes and complement C3 levels were significantly higher in the cGVHD group (
conclusionsThe development of cGVHD is closely associated with T-cell homeostasis imbalance, B-cell functional exhaustion, and abnormal activation of the complement system. The percentage of helper/inducer T lymphocytes and complement C3 levels may serve as potential predictive indicators for cGVHD occurrence.
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