ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2026
[Impact of optimizing the quality control system on newborn screening outcomes for congenital hypothyroidism].
Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo evaluate the impact of an optimized quality control system on neonatal screening outcomes for congenital hypothyroidism (CH).
methodsScreening data from 2013 to 2023 were retrospectively collected. Quality indicators were compared between the pre-optimization period (2013-2018) and the post-optimization period (2019-2023). The relationship between initial thyroid-stimulating hormone (TSH) screening values and positive predictive value (PPV) was examined.
resultsA total of 1 264 541 neonates were screened, with a screening rate of 90.23%. The recall rate for initially positive cases was 94.87%, and the loss-to-follow-up rate was 5.13%. CH was confirmed in 419 infants, yielding a detection rate of 0.33‰ and a PPV of 3.60%. The median age at treatment initiation was 32 days. Compared with the pre-optimization period, the post-optimization period showed higher recall rate for initial positives, higher positivity among recalled cases, and higher CH detection rate, alongside a lower loss-to-follow-up rate; the age at treatment initiation was also reduced (all
conclusionsOptimizing the quality control system improves the quality of neonatal CH screening. Prioritizing the recall of neonates with initial TSH values ≥20.0 mIU/L may contribute to better prognosis.
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