ArticleVox sanguinis2026
Marginal anaemia and perioperative transfusion in female patients undergoing cardiac surgery.
Article in Vox sanguinis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Clinical and Economic Outcomes Associated with Structured Preoperative Anemia Management in Elective Cardiac Surgery: A Patient Blood Management Cohort Study.Journal of clinical medicine · 2026Article
- Marginal anaemia and perioperative transfusion in female patients undergoing cardiac surgery.Vox sanguinis · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesFemales undergoing cardiac surgery frequently require allogeneic blood transfusion, yet sex-specific haemoglobin (Hb) thresholds may underestimate physiological vulnerability in these patients. Recent evidence suggests that Hb values between 12.0 and 12.9 g/dL may represent marginal anaemia with clinically relevant consequences. This study assessed the impact of preoperative Hb on perioperative transfusion in females undergoing elective cardiac surgery. Anaemia categories were defined as follows: World Health Organization (WHO) anaemia (<12 g/dL in females); marginal anaemia (Hb 12.0-12.9 g/dL in females); and patient blood management (PBM)-defined anaemia (<13 g/dL irrespective of sex). MATERIALS AND
methodsWe conducted a retrospective analysis of 1174 cardiac surgery patients, including 399 females. Females were stratified into three groups: Hb ≥13 g/dL, 12-13 g/dL and <12 g/dL. Perioperative outcomes and predictors of packed red blood cell (PRBC) transfusion were evaluated using multivariable logistic regression. Model performance was assessed using receiver operating characteristic (ROC) curve analysis.
resultsTransfusion rates increased stepwise across Hb strata: 57.3% (≥13 g/dL), 69.6% (12.0-12.9 g/dL) and 87.0% (<12 g/dL) (p <0.001). Females with marginal anaemia (12.0-12.9 g/dL) received more PRBC units per patient than both non-anaemic females and males in the same Hb range. In multivariable analysis, marginal anaemia (odds ratio [OR] 2.05; 95% confidence interval [CI]: 1.39-3.03) and overt anaemia (OR 6.33; 95% CI: 4.40-9.97) remained independent predictors of transfusion.
conclusionMarginal anaemia in females undergoing cardiac surgery is associated with an increased risk of perioperative transfusion. Females with marginal anaemia had higher transfusion rates than those with Hb ≥13 g/dL, although quantitatively distinct from overt anaemia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.