ArticleMagnetic resonance in medicine2026
Oxygen Response Index: A Potential OE-MRI-Derived Non-Invasive Biomarker for Assessing Radiation Treatment Efficacy.
Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThe goal of this study was to develop an optimized oxygen-enhanced MRI (OE-MRI) protocol for longitudinal monitoring of tumor oxygenation during radiation therapy in a pre-clinical model and to introduce the Oxygen Response Index (ORI) as a potential early biomarker of treatment efficacy.
methodsA high-throughput mouse imaging protocol was designed for a clinical 3 T MRI system using optimized variable flip angle T
resultsDuring fractionated irradiation, ORI declined progressively, with the change-point analysis identifying treatment response inflection at scan 4 (day 8), one scan interval before tumor volume at scan 5 (day 10). After the 60-Gy dose, conversion of putatively hypoxic tissue to oxygen-responsive tissue was observed. Spatial analysis revealed persistent oxygen-response gradients, with tumor regions adjacent to normoxic tissue demonstrating greater responsiveness than non-adjacent tumor areas.
conclusionORI captured longitudinal changes in tumor oxygenation during both ineffective and effective treatment phases and may provide a useful complementary biomarker for monitoring treatment response.
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