ArticleThe Journal of infectious diseases2026
Characterizing the Circulation of Gametocytes and Mosquito Infectivity in Induced Blood Stage Malaria.
Article in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundUnderstanding the influence of gametocyte dynamics on transmission of Plasmodium falciparum from humans to mosquitoes may support malaria elimination initiatives.
methodsLongitudinal parasitemia, gametocytemia, and mosquito transmission data from 91 participants in 9 controlled human malaria infection studies conducted in Brisbane, Australia (n = 8) and Nijmegen, the Netherlands (n = 1) were analyzed to explore the relationship of parasite and participant characteristics on gametocytes and transmission. Transmission potential estimated using Poisson probabilities was compared to transmission to Anopheles stephensi mosquitoes assessed using direct and membrane feeding assays across 5 clinical trials and 30 participants.
resultsMaximum gametocyte density over time per participant was positively correlated with asexual parasitemia at time of first treatment (ρ minimum = 0.44, maximum = 0.89). Median maximum gametocyte densities occurring 19-21 days postinoculation were 1087 gametocytes/mL for female and 219 gametocytes/mL for male gametocytes. Both female and male gametocyte densities were higher among individuals who infected mosquitoes, as were pretreatment parasite growth rates and parasite densities. Infectivity rates varied between 53% and 54% for direct skin, 29% and 33% for direct membrane, 54% and 100% for membrane after serum replacement, and 89% and 100% for enriched membrane feeding assays. Potential for transmission was correctly predicted for 71%-74% of direct feeding assays and 50%-78% of membrane after serum replacement feeding assays.
conclusionsThis study confirms that transmissible gametocyte densities can be consistently achieved in controlled infections. Higher asexual densities and growth rates were associated with higher gametocyte densities and higher transmission. Detailed understanding of how low-level gametocytemia contributes to transmission will guide both experimental infection studies and interventions to interrupt transmission.
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