Evidence map›Paper›PMID 42304545›Full record

ArticlePest management science2026

PDK1-mediated PI3K/Akt signaling regulates metabolic and developmental programs in a cosmopolitan pest.

Minghui Yan, Liangqian Xie, Bingxue Li, Jianghong Hu, Bingwei Chen, Minsheng You, Yuanyuan Liu, Geoff M Gurr, Jinyang Li, Shijun You

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Minghui Yan *State Key Laboratory of Agricultural and Forestry Biosecurity, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou, China.
Liangqian Xie *State Key Laboratory of Agricultural and Forestry Biosecurity, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou, China.
Bingxue LiState Key Laboratory of Agricultural and Forestry Biosecurity, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou, China.
Jianghong HuState Key Laboratory of Agricultural and Forestry Biosecurity, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou, China.
Bingwei ChenState Key Laboratory of Agricultural and Forestry Biosecurity, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou, China.
Minsheng YouState Key Laboratory of Agricultural and Forestry Biosecurity, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou, China.ORCID https://orcid.org/0000-0001-9042-6432
Yuanyuan LiuHaixia Institute of Science and Technology, Fujian Agriculture and Forestry University, Fuzhou, China.
Geoff M GurrState Key Laboratory of Agricultural and Forestry Biosecurity, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou, China.ORCID https://orcid.org/0000-0001-5008-7966
Jinyang LiState Key Laboratory of Agricultural and Forestry Biosecurity, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou, China.
Shijun YouState Key Laboratory of Agricultural and Forestry Biosecurity, Institute of Applied Ecology, Fujian Agriculture and Forestry University, Fuzhou, China.ORCID https://orcid.org/0000-0001-7340-1524

Funding

The Chuying Program for the Top Young Talents of Fujian Province
6 · The paper itself

Abstract

background3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a central kinase in the phosphatidylinositol 3-kinase/serine-threonine kinase (PI3K/Akt) pathway that integrates growth and nutrient signals to regulate metabolism and development across diverse animal taxa. However, its functions in insects remain ambiguous.

resultsHere, we identify and characterize PxPDK1 in the diamondback moth, Plutella xylostella, a major agricultural pest. PxPDK1 encodes a conserved kinase containing serine/threonine kinase and pleckstrin homology domains, and is highly expressed during embryonic, pupal and adult stages. CRISPR/Cas9-mediated knockout of PxPDK1 resulted in developmental delay, failure of pupal-adult eclosion, impaired ovarian development, and sharply reduced fecundity and egg hatchability. Loss of PxPDK1 attenuated Akt phosphorylation and disrupted genes involved in metabolism, reproduction and cuticle formation, accompanied by decreased adult glycogen content. Conversely, PxPDK1 expression promoted Sf9 cell proliferation.

conclusionThese findings establish PxPDK1 as an essential regulator of insect development and metabolism, highlighting PDK1 as a promising molecular target for pest control. © 2026 Society of Chemical Industry.

Indexed as

3-Phosphoinositide-Dependent Protein KinasesInsect ProteinsMothsProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktSignal TransductionAnimalsFemalePhosphatidylinositol 3-KinasesPupa3-Phosphoinositide-Dependent Protein KinasesInsect ProteinsPhosphatidylinositol 3-KinasesProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktCRISPR/Cas9PDK1PI3K/AKTPlutella xylostellareproduction

Identifiers

PMID42304545
PMCPMC13569167

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.