ArticlePorcine health management2026
Characterization of Pestivirus scrofae infection in the tissues of a persistently infected boar.
Article in Porcine health management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPestivirus scrofae (previously atypical porcine pestivirus, APPV) is a member of the genus Pestivirus within the family Flaviviridae. This virus has been established as the etiological agent of congenital tremor (CT) type AII, a neurological disorder in newborn piglets characterized by generalized tremors. Despite this association, the epidemiological characteristics of the virus, including its transmission dynamics and patterns of spread between herds, remain poorly understood. It has already been confirmed that, similarly to other flaviviruses, APPV can be shed by semen. Previously, we have identified interstitial Leydig cells, the peritubular myoid cells and smooth muscle cells of medium-sized arteries as target cells of APPV in the testicles of newborn, congenitally infected, CT-affected piglets.
resultsIn our present study, we examined FFPE tissue samples obtained from a persistently infected 6-months-old, sexually mature boar, born with CT, that was still shedding 2.1 × 10
conclusionOur results suggest that APPV is capable of crossing the blood-testis barrier, and may be associated with persistent infection, including cases likely originating from congenital exposure, in pigs and boars that can actively shed the virus. Therefore, the use of such animals for breeding purposes should be approached with caution. Further research is needed to elucidate the underlying mechanisms of persistent infection.
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