ArticleGut pathogens2026
Fungal abundance across flare and remission in ulcerative colitis patients.
Article in Gut pathogens, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
backgroundUlcerative colitis (UC) is associated with gut microbiota alterations, but the role of the fungal microbiota remains underexplored. We conducted a prospective study quantifying absolute bacterial and fungal abundance in faecal samples from UC patients with varying disease activity.
methodsWe amplified the ITS2 sequence (fungi) and 16 S rRNA gene (bacteria) in three groups of patients: UC long remission (UClr); UC short remission (UCsr) and UC flare (UCfl). Two faecal samples from UClr and UCsr, and one sample from UCfl group (at flare-onset) were collected.
resultsEighty-seven patients were included: 29 UClr, 20 UCsr, and 38 UCfl. Across all patients, fungal ITS2 gene copies were markedly lower than bacterial 16 S rRNA copies (median 9.27E + 05 vs. 4.28E + 11 copies/g), with a fungal-to-bacterial ratio of 1:461,000. Fungal abundance was significantly higher in UCfl than in UClr (p = 0.0026), but not UCsr. The ITS2/16S ratio was also elevated in UCfl versus both remission groups (p < 0.01). Over time, fungal abundance showed greater variability than bacterial abundance, with a modest but significant decrease in the ITS2/16S ratio at 8 weeks (p = 0.029).
conclusionWhile bacterial loads remained stable across disease states, fungal abundance and the fungal-to-bacterial ratio were higher during UC flares. These findings describe an association between fungal dynamics and disease activity in UC and support further investigation of inter-kingdom microbial relationships in this context.
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