ReviewFluids and barriers of the CNS2026
Targeting CD4⁺ T cell infiltration: mechanisms and therapeutic insights into CD4⁺ T cell transmigration across the blood-brain barrier in acute ischemic stroke.
Review in Fluids and barriers of the CNS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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13 authors.
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Abstract
The blood-brain barrier (BBB) serves as a physical barrier of the central nervous system, characterized by selective permeability and immune isolation. It plays a critical role in transporting essential nutrients for normal neuronal metabolism while preventing the entry of toxic substances into the brain. Following acute ischemic stroke, the integrity of the BBB is compromised, leading to extensive T-cell infiltration into the brain. These infiltrating T cells influence BBB permeability and can exert either protective or detrimental effects on brain tissue. Current research has largely focused on the subset-specific regulation of T cells after their infiltration or on inhibiting T-cell migration into the brain during ischemic stroke. However, a systematic understanding of the routes and mechanisms underlying T-cell trafficking across the BBB in this context remains limited. In this review, we systematically examine the functional alterations of the BBB induced by different CD4
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