ArticleJournal of nanobiotechnology2026
Functional-responsive hydrogel microspheres based on microenvironment sensing promote the sequential repair of infected bone defects by regulating ROS balance.
Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Local drug delivery systems for the periodontal microenvironment: from barrier penetration to multilevel synergy.Frontiers in pharmacology · 2026Review
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Authors and funding
12 authors.
Funding
Abstract
backgroundThe key to treating infectious bone defects (IBD) is regulating reactive oxygen species (ROS) balance to achieve "anti-infective first, then osteogenesis" temporal sequential repair. However, sensing microenvironmental changes to regulate ROS remains challenging. This study prepared a nanoparticle (PBD-ICG nanoparticlces) capable of sensing pH changes to enable protonation and deprotonation with "triple-element synergy" acid-base-driven assembly method, and loaded onto GelMA/HAMA hydrogel microsphere established a functional-responsiveness hydrogel microsphere (PGI) based on microenvironment sensing.
resultWith ultrasonic cavitation, indocyanine green transition to excited state, enabling electron transfer or energy transfer with H
conclusionSummarizing, this system regulates ROS balance through sensing of microenvironment to achieve functional-responsive temporal sequential repair, providing novel strategies for IBD synergistic repair.
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