Evidence map›Paper›PMID 42304434›Full record

ArticleLipids in health and disease2026

Differential associations of lipid profile and genetic susceptibility with sleep duration.

Zihao Zhang, Yuanyuan Zhang, Ziyi Peng, Yirong Yang, Kuan Ning, Yijia Chen, Yuhe Wu, Xuerui Yao, Hailun Wu, Yifan Wang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zihao Zhang *Institute of Neurology, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330200, China.
Yuanyuan Zhang *Institute of Neurology, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330200, China.
Ziyi Peng *Institute of Neurology, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330200, China.
Yirong YangInstitute of Neurology, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330200, China.
Kuan NingInstitute of Neurology, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330200, China.
Yijia ChenInstitute of Neurology, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330200, China.
Yuhe WuInstitute of Neurology, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330200, China.
Xuerui YaoInstitute of Neurology, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330200, China.
Hailun WuInstitute of Neurology, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330200, China.
Yifan WangInstitute of Neurology, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330200, China.
Hancun YiDepartment of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Dandan TanDepartment of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Tanxiu ChenInstitute of Neurology, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330200, China.
Daojun HongInstitute of Neurology, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330200, China. hdj@ncu.edu.cn.
Wen-Quan ZouInstitute of Neurology, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, 330200, China. wenquanzou@ncu.edu.cn.

Funding

Jiangxi Key Laboratory of Neurological Diseases 2024SSY06072National Natural Science Foundation 82471499the startup package and developmental funds of the First Affiliated Hospital of Nanchang University #500021001, #500021002
6 · The paper itself

Abstract

backgroundLipid metabolism is influenced by multiple factors, and its association with sleep duration may vary across lipid fractions. Lipid levels and their genetic susceptibility have been associated with sleep duration; however, these associations are heterogeneous, and it remains unclear whether specific lipid components exhibit more consistent associations with sleep duration.

methodsThis study included 410,493 participants from the UK Biobank. Multivariable linear regression (MLR) was used to assess the associations of triglycerides (TG), total cholesterol (TC), and low-density lipoprotein (LDL) with sleep duration. Polygenic risk scores (PRSs) were incorporated to evaluate genetic susceptibility. Interaction terms between lipid levels and PRSs were included in multivariable models. Cox proportional hazards models were used to examine the associations of lipid levels and PRSs with sleep disorders. Joint exposure analyses of lipid levels and PRSs were performed, and interaction effects were assessed. Restricted cubic spline models were further applied to evaluate potential non-linear associations. Proteomic analyses were conducted to explore proteomic features associated with both lipid profile and sleep duration.

resultsMLR analyses showed that TG levels were positively associated with sleep duration (β = 0.027, P < 0.001), whereas TC levels were inversely associated with sleep duration (β = -0.005, P = 0.005). No significant association was observed for LDL. In contrast, PRSs for TG, TC, and LDL were consistently inversely associated with sleep duration. A significant interaction was observed between TG and their PRS (β = -0.009, p < 0.001). TG and PRS-TG were associated with higher risks of sleep disorders (6.9% and 3.2% per unit increase), with a significant interaction (p = 0.014). Elevated risks were observed in high TG groups, while TC and LDL were not significant. Both lipid traits and sleep duration were mainly enriched in immune and inflammatory pathways.

conclusionsTriglycerides showed the most consistent associations with sleep duration, and TG-related genetic susceptibility may influence TG levels and their associations with sleep duration and sleep disorders.

Indexed as

Genetic Predisposition to DiseaseLipidsSleep Wake DisordersAgedCholesterolFemaleGenetic Risk ScoreHumansLipid MetabolismMaleMiddle AgedSleep DurationTriglyceridesCholesterolLipidsTriglyceridesLipidSleep disordersSleep durationTriglycerides

Identifiers

PMID42304434
PMCPMC13435583

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.