Evidence map›Paper›PMID 42304380›Full record

ArticleJournal of neuroinflammation2026

Human iPSC-derived neurons stimulated with IFNγ present HLA class I-restricted antigens to cytotoxic CD8

Benjamin Ds Clarkson, Susanna Pucci, Brittany L Overlee, Ramila Barun Shrestha, Kiran K Mangalaparthi, Remya Raja, Pei Shang, Marion Curtis, Akhilesh Pandey, Charles L Howe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Benjamin Ds ClarksonTranslational Neuroimmunology Laboratory, Mayo Clinic, Guggenheim 1542C; 200 First St SW, Rochester, MN, 55905, USA.
Susanna PucciTranslational Neuroimmunology Laboratory, Mayo Clinic, Guggenheim 1542C; 200 First St SW, Rochester, MN, 55905, USA.
Brittany L OverleeTranslational Neuroimmunology Laboratory, Mayo Clinic, Guggenheim 1542C; 200 First St SW, Rochester, MN, 55905, USA.
Ramila Barun ShresthaTranslational Neuroimmunology Laboratory, Mayo Clinic, Guggenheim 1542C; 200 First St SW, Rochester, MN, 55905, USA.
Kiran K MangalaparthiDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Remya RajaDepartment of Immunology, Mayo Clinic, Phoenix, AZ, USA.
Pei ShangTranslational Neuroimmunology Laboratory, Mayo Clinic, Guggenheim 1542C; 200 First St SW, Rochester, MN, 55905, USA.
Marion CurtisDepartment of Immunology, Mayo Clinic, Phoenix, AZ, USA.
Akhilesh PandeyDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Charles L HoweTranslational Neuroimmunology Laboratory, Mayo Clinic, Guggenheim 1542C; 200 First St SW, Rochester, MN, 55905, USA. howe@mayo.edu.ORCID http://orcid.org/0000-0002-3889-8739

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3M
Mayo Clinic Center for Clinical ProteomicsU01CA271410 · NCI · MAYO CLINIC ROCHESTER · PI Rafael Fonseca, AKHILESH PANDEY · 2022 to 2026
$5.3M
Mechanisms of neuronal injury during virus infection of the CNSR01NS064571 · NINDS · MAYO CLINIC ROCHESTER · PI HOWE, CHARLES LEE · 2009 to 2018
$3.0M
NCI NIH HHS P30 CA015083NCI NIH HHS U01 CA271410NCI NIH HHS U01CA271410NINDS NIH HHS NS064571NINDS NIH HHS R01 NS064571
6 · The paper itself

Abstract

Multiple sclerosis lesions are dominated by clonally expanded CD8

Indexed as

CD8-Positive T-LymphocytesHistocompatibility Antigens Class IInduced Pluripotent Stem CellsInterferon-gammaNeuronsT-Lymphocytes, CytotoxicCells, CulturedCoculture TechniquesHumansHistocompatibility Antigens Class IInterferon-gammaAntigen presentationCD8+ T cellsHLA class IImmunopeptidomicsInduced pluripotent stem cellsInterferon-γ (IFNγ)Neural organoidNeuroinflammation

Identifiers

PMID42304380
PMCPMC13508380

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.