Trial reportBMC oral health2026
Analysis of the impact of contemporary subgingival debridement techniques on immunological biomarkers in gingival crevicular fluid.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimIn non-surgical periodontal therapy, periodontal curettes are used for scaling and root planing, which is considered a standard approach for the management of mild to moderate periodontitis. This prospective clinical study aimed to evaluate the efficacy of two distinct non-surgical periodontal therapy modalities in patients diagnosed with Stage 1 and Stage 2 periodontitis.
methodThe study comprised 80 nonsmoking, systemically healthy volunteers. Patients were divided into two groups at random: the Guided Biofilm Therapy (GBT) group and the conventional therapy group (CT), which included Gracey curette and an ultrasonic device. All patients were assessed before and one and three months after therapy for clinical characteristics like pocket depth (PD), Gingival Index (GI), Plaque Index (PI), Bleeding on Probing Index (BOP), and the levels of IL-1β, IL-10, TNF-α, and MMP-8 in gingival crevicular fluid (GCF).
resultsOver time, both treatment approaches significantly improved all indicators (p < 0.001). At 1 and 3 months, the GBT group showed a more substantial decrease in GI, PI, and IL-1β levels than the standard treatment group (p < 0.05). However, no significant differences were found between the groups in TNF-α, IL-10, and MMP-8 levels.
conclusionThe information gathered shows that guided biofilm therapy is a viable choice, especially for managing plaque and lowering the inflammatory response. These findings emphasize the value of contemporary methods for treating periodontal disease that incorporate patient motivation. CLINICAL RELEVANCE: To date, no studies have evaluated the impact of current subgingival debridement techniques on immunological biomarkers in gingival crevicular fluid. Our findings suggest that guided biofilm therapy may be more effective in reducing gingival inflammation compared to conventional approaches. Studies involving more participants and longer follow-up durations are necessary to support these conclusions.
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