Evidence map›Paper›PMID 42304327›Full record

ArticleBMC oral health2026

Novel injectable and wet bonding bone adhesive: physicochemical characterization and biocompatibility evaluation.

Guibin Huang, Bingqing Li, Yining Liu, Xiwen Zhang, Hongzhi Zhou, Jian Wang, Peng Yu

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In one paragraph

Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Guibin Huang *Department of Cariology and Endodontology II, Xiamen Key Laboratory of Stomatological Disease Diagnosis and Treatment, Stomatological Hospital of Xiamen Medical College, Xiamen, 361000, China.
Bingqing Li *Department of General Dentistry, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Yining LiuDepartment of Cariology and Endodontology, Peking University School and Hospital of Stomatology and National Center for Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, 100081, China.
Xiwen ZhangDepartment of Cariology and Endodontology, Peking University School and Hospital of Stomatology and National Center for Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, 100081, China.
Hongzhi ZhouDepartment of Stomatology, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing, 100049, China.
Jian WangSuzhou Jiuxin Medical Technology Co., LTD, Suzhou, 215000, China.
Peng YuDepartment of Cariology and Endodontology, Peking University School and Hospital of Stomatology and National Center for Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, 100081, China. yupeng@bjmu.edu.cn.

Funding

Clinical Medicine Plus X Young Scholars Project of Peking University PKU2021LCXQ029Science and Technology Innovation Joint Fund project of Fujian province 2025Y9743
6 · The paper itself

Abstract

backgroundBone defect repair is the common clinical dilemmas in surgery, whereas conventional repair materials are limited by poor wet bonding performance, inadequate biocompatibility or the need for secondary surgical removal. To address the above clinical challenges and material defects, this study developed a novel injectable bone adhesive suitable for wet conditions.

methodsA novel injectable wet-bonding bone adhesive (Bone Glue) was fabricated with bioactive glass, tetracalcium phosphate (TTCP), polyglycolic acid (PGA) fibers, phosphoserine (PS) and phosphate solution as raw materials. Its physicochemical properties were characterized, and in vitro cytotoxicity on L-929 cells was assessed by Methyl thiazolyl tetrazolium (MTT) assay; 12-week subchronic systemic toxicity test in SD rats was performed to evaluate in vivo biosafety.

resultsThe Bone glue was injectable. Curing triggered structural cross-linking of Bone Glue, with its adhesive strength to titanium increasing from 0.91 ± 0.14 MPa (initial curing) to 1.26 ± 0.09 MPa (complete curing, P < 0.05). The extract maintained a near-physiological pH (7.30-7.35) for 72 h, and all concentrations exhibited > 70% L-929 cell viability. In vivo, no abnormal symptoms, pathological lesions or significant body weight differences were observed in the Bone Glue group, with minor hematological/biochemical variations within normal ranges.

conclusionsBone glue possesses favorable physicochemical properties and excellent in vitro/in vivo biocompatibility, which makes it a promising biomaterial for dental implant fixation and bone defect repair in minimally invasive clinical applications.

Indexed as

Biocompatible MaterialsBone CementsAnimalsCalcium PhosphatesCell LineCell SurvivalGlassInjectionsMaleMaterials TestingMiceRatsRats, Sprague-DawleyTitaniumBiocompatible MaterialsBone CementsCalcium Phosphatestetracalcium phosphateTitaniumAdhesive strengthBiocompatibilityBone adhesiveBone repairDental implant

Identifiers

PMID42304327
PMCPMC13531784

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