Evidence map›Paper›PMID 42304249›Full record

ArticleBMC genomics2026

Genomic analysis reveals close genetic similarity between ESBL and other β-lactamase-producing E. coli isolates from humans and dogs, suggesting potential for inter-species transmission.

Charles E Whitehead-Tillery, Samantha E Waite, Gabriel A E Durand-Piña, Elizabeth K Green, Julia A Bell, Lixin Zhang, Linda S Mansfield

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Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Charles E Whitehead-TilleryDepartment of Microbiology, Genetics and Immunology, Michigan State University, East Lansing, MI, United States.
Samantha E WaiteDepartment of Microbiology, Genetics and Immunology, Michigan State University, East Lansing, MI, United States.
Gabriel A E Durand-PiñaSummer Research Opportunities Program, The Graduate School, Michigan State University, East Lansing, MI, United States.
Elizabeth K GreenCollege of Natural Science, Michigan State University, East Lansing, MI, United States.
Julia A BellDepartment of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI, United States.
Lixin ZhangDepartment of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, United States.
Linda S MansfieldDepartment of Microbiology, Genetics and Immunology, Michigan State University, East Lansing, MI, United States. mansfie4@msu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExtended-spectrum β-lactamase-(ESBL)-producing Enterobacteriaceae are emerging in hospital and community settings as important causes of urinary tract infections. These plasmid-mediated enzymes have been identified in human and dog hosts, with bla

resultsOf 149 plasmids collected from humans (n = 125) and dogs (n = 24), 111 (74.5%) carried class A ESBL genes with bla

conclusionsThe presence of conserved ESBLs, other β-lactamase genes and E. coli clones in both humans and dogs highlights widespread circulation of shared resistance elements. These findings support the need for broader One Health surveillance, particularly involving companion animals, to better track and mitigate ARG spread in community settings.

Indexed as

beta-LactamasesEscherichia coliEscherichia coli InfectionsGenomicsAnimalsDogsGene Transfer, HorizontalGenome, BacterialHumansPhylogenyPlasmidsbeta-LactamasesAntibiotic resistanceCommunity-acquiredComparative genomicsEscherichia coliExtended-spectrum β-lactamase (ESBL) producing EnterobacteriaceaeHorizontal gene transfer (HGT)Humans and dogsUropathogenic E. coli (UPEC)

Identifiers

PMID42304249
PMCPMC13505036

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.