Evidence map›Paper›PMID 42304219›Full record

ArticleBMC plant biology2026

HAM1 negatively regulates drought tolerance in Brassica juncea.

Yiqing Meng, Zhuting Liu, Jianeng Che, Zhangping Li, Xiaoxiao Guan, Yimei Zhou, Yongming Bo, Xiaolong Lyu, Zhongyuan Hu, Jinghua Yang and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC plant biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yiqing MengLaboratory of Germplasm Innovation and Molecular Breeding, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Zhuting LiuLaboratory of Germplasm Innovation and Molecular Breeding, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Jianeng CheLaboratory of Germplasm Innovation and Molecular Breeding, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Zhangping LiLaboratory of Germplasm Innovation and Molecular Breeding, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Xiaoxiao GuanLaboratory of Germplasm Innovation and Molecular Breeding, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Yimei ZhouLaboratory of Germplasm Innovation and Molecular Breeding, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Yongming BoKey Laboratory of Digital Breeding Enterprises for Melons and Pakchoi, Ningbo Weimeng Seed Industry Co.Ltd, Ningbo, China.
Xiaolong LyuLaboratory of Germplasm Innovation and Molecular Breeding, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Zhongyuan HuLaboratory of Germplasm Innovation and Molecular Breeding, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Jinghua YangLaboratory of Germplasm Innovation and Molecular Breeding, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Mingfang ZhangLaboratory of Germplasm Innovation and Molecular Breeding, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China. mfzhang@zju.edu.cn.

Funding

Chengxi Innovation Corridor Project B231220.0005-25National Natural Science Foundation of China 32030092
6 · The paper itself

Abstract

Drought stress poses a severe and growing threat to global crop production due to climate change. Brassica juncea is an important vegetable and oil crop with high potential for cultivation in arid and semi-arid regions, yet its genetic mechanisms underlying drought resilience remain poorly understood. Here, we evaluated the phenotypes of geographically diverse B. juncea accessions under drought stress and identified a candidate gene BjuB.HAM1 via genome-wide association study (GWAS) approach, a plant-specific GRAS-family transcription factor, as a key negative regulator of drought tolerance. We discovered two structural variations (SVs) within BjuB.HAM1 that significantly impair drought tolerance in B. juncea. Using heterologous expression of BjuB.HAM1 in Arabidopsis thaliana, combined with downstream gene validation, we demonstrated that this gene inhibits the expression of AtUGT76C2, a cytokinin glycosyltransferase, and reduces drought tolerance by binding to its GT cis-elements in the promoter. Collectively, these findings uncover a new insight into the functional gene module of drought resistance, and provide valuable genetic targets for drought resistance breeding in Brassica juncea.

Indexed as

Mustard PlantPlant ProteinsTranscription FactorsArabidopsisDrought ResistanceDroughtsGene Expression Regulation, PlantGenome-Wide Association StudyPlant ProteinsTranscription FactorsBrassica junceaDrought toleranceGWASHAM1Negative regulator

Identifiers

PMID42304219
PMCPMC13501682

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.