Evidence map›Paper›PMID 42304218›Full record

ArticleBMC genomics2026

Sheep erythrocyte potassium locus highlights MYADM family regulation of electroneutral potassium chloride cotransporters (KCC).

Michael V Gonzalez, Michelle R Mousel, David R Herndon, Alisha T Massa, Codie J Durfee, Donald P Knowles, J Bret Taylor, Holly L Neibergs, Christopher M Seabury, Stephen N White

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michael V GonzalezAnimal Disease Research Unit, Agricultural Research Service, Department of Agriculture, Pullman, WA, 99164, USA.
Michelle R MouselAnimal Disease Research Unit, Agricultural Research Service, Department of Agriculture, Pullman, WA, 99164, USA.
David R HerndonAnimal Disease Research Unit, Agricultural Research Service, Department of Agriculture, Pullman, WA, 99164, USA.
Alisha T MassaDepartment of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA, 99164, USA.
Codie J DurfeeAnimal Disease Research Unit, Agricultural Research Service, Department of Agriculture, Pullman, WA, 99164, USA.
Donald P KnowlesAnimal Disease Research Unit, Agricultural Research Service, Department of Agriculture, Pullman, WA, 99164, USA.
J Bret TaylorU.S. Sheep Experiment Station, Agricultural Research Service, Department of Agriculture, Dubois, ID, 83423, USA.
Holly L NeibergsDepartment of Animal Sciences, Washington State University, Pullman, WA, 99164, USA.
Christopher M SeaburyVeterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77843, USA.
Stephen N WhiteAnimal Disease Research Unit, Agricultural Research Service, Department of Agriculture, Pullman, WA, 99164, USA. Stephen.White@usda.gov.

Funding

ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Achievement Rewards for College Scientists Foundation ARCS FellowshipAgricultural Research Service 2090-32000-046-00DAmerican Sheep Industry Association Sheep Heritage Foundation Memorial ScholarshipNIGMS NIH HHS R01 GM129325Washington State University distinguished combined D.V.M. residency/Ph.D. program fellowshipWashington State University DRADS assistantship
6 · The paper itself

Abstract

Some domestic sheep have distinct low (LK) or high intracellular potassium (HK) erythrocytes with demonstrated differences in potassium chloride co-transport. Erythrocyte potassium concentration is inherited as a single locus trait, although responsible genetic variant(s) have not been identified. Herein, genome-wide association identified a large, artiodactyl-specific tandem duplication of the MYADM gene family locus as highly associated (P = 1.1 × 10

Indexed as

ErythrocytesGenetic LociPotassiumSymportersAnimalsGenome-Wide Association StudyK Cl- CotransportersMultigene FamilySheepK Cl- CotransportersPotassiumSymportersAlphaFold3CattleErythrocyteGoatGWASHypertensionKCCKCC3ALivestockMYADMMYADMFN-terminal peptidePigPotassium chloride co-transportSheep

Identifiers

PMID42304218
PMCPMC13508224

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.