Evidence map›Paper›PMID 42304162›Full record

ArticleAging cell2026

Human iPSC-NSC-Derived Extracellular Vesicles Can Alleviate Alzheimer's Disease-Linked Impairments in Mitochondria, mTOR Signaling, Autophagy, and Hippocampal Neurogenesis.

Leelavathi N Madhu, Sahithi Attaluri, Sanya Kotian, Raghavendra Upadhya, Yogish Somayaji, Shama Rao, Prashant Tarale, Shruthi V Ganesh, Charles Huard, Maheedhar Kodali and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Leelavathi N MadhuInstitute for Regenerative Medicine, Department of Cell Biology and Genetics, Texas A&M University Naresh K Vashisht College of Medicine, Bryan/College Station, Texas, USA.
Sahithi AttaluriInstitute for Regenerative Medicine, Department of Cell Biology and Genetics, Texas A&M University Naresh K Vashisht College of Medicine, Bryan/College Station, Texas, USA.
Sanya KotianInstitute for Regenerative Medicine, Department of Cell Biology and Genetics, Texas A&M University Naresh K Vashisht College of Medicine, Bryan/College Station, Texas, USA.
Raghavendra UpadhyaInstitute for Regenerative Medicine, Department of Cell Biology and Genetics, Texas A&M University Naresh K Vashisht College of Medicine, Bryan/College Station, Texas, USA.
Yogish SomayajiInstitute for Regenerative Medicine, Department of Cell Biology and Genetics, Texas A&M University Naresh K Vashisht College of Medicine, Bryan/College Station, Texas, USA.
Shama RaoInstitute for Regenerative Medicine, Department of Cell Biology and Genetics, Texas A&M University Naresh K Vashisht College of Medicine, Bryan/College Station, Texas, USA.
Prashant TaraleInstitute for Regenerative Medicine, Department of Cell Biology and Genetics, Texas A&M University Naresh K Vashisht College of Medicine, Bryan/College Station, Texas, USA.
Shruthi V GaneshInstitute for Regenerative Medicine, Department of Cell Biology and Genetics, Texas A&M University Naresh K Vashisht College of Medicine, Bryan/College Station, Texas, USA.
Charles HuardInstitute for Regenerative Medicine, Department of Cell Biology and Genetics, Texas A&M University Naresh K Vashisht College of Medicine, Bryan/College Station, Texas, USA.
Maheedhar KodaliInstitute for Regenerative Medicine, Department of Cell Biology and Genetics, Texas A&M University Naresh K Vashisht College of Medicine, Bryan/College Station, Texas, USA.ORCID https://orcid.org/0000-0003-0741-4401
Bing ShuaiInstitute for Regenerative Medicine, Department of Cell Biology and Genetics, Texas A&M University Naresh K Vashisht College of Medicine, Bryan/College Station, Texas, USA.
Vidya V RaoInstitute for Regenerative Medicine, Department of Cell Biology and Genetics, Texas A&M University Naresh K Vashisht College of Medicine, Bryan/College Station, Texas, USA.
Ashok K ShettyInstitute for Regenerative Medicine, Department of Cell Biology and Genetics, Texas A&M University Naresh K Vashisht College of Medicine, Bryan/College Station, Texas, USA.ORCID https://orcid.org/0000-0001-5049-6671

Funding

Intranasal Treatment of Stem Cell-derived Extracellular Vesicles for Alzheimer's DiseaseRF1AG074256 · NIA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI SHETTY, ASHOK K · 2022 to 2025
$3.6M
Neural Stem Cell-derived EVs for Improving Aged Brain FunctionR01AG075440 · NIA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ASHOK K SHETTY · 2022 to 2026
$2.9M
NIA NIH HHS R01 AG075440NIA NIH HHS R01AG075440NIA NIH HHS RF1 AG074256NIA NIH HHS RF1AG074256
6 · The paper itself

Abstract

Intranasal (IN) administrations of extracellular vesicles (EVs) derived from human-induced pluripotent stem cell (hiPSC)-derived neural stem cells (hNSCs) have shown promise in reducing chronic neuroinflammation mediated by microglia and astrocytes in 5x familial Alzheimer's disease (5xFAD) mice, a model for early-onset Alzheimer's disease (AD). The current study rigorously investigated whether treatment with hiPSC-NSC-EVs could also alleviate several other neuropathological changes contributing to progressive cognitive decline. Three-month-old male and female 5xFAD mice received IN administrations of either hiPSC-NSC-EVs (~30 × 10

Indexed as

Alzheimer DiseaseAutophagyExtracellular VesiclesHippocampusInduced Pluripotent Stem CellsMitochondriaNeural Stem CellsNeurogenesisTOR Serine-Threonine KinasesAnimalsFemaleHumansMaleMiceSignal TransductionTOR Serine-Threonine KinasesAlzheimer's diseaseautophagyhippocampal neurogenesismitochondrial dysfunctionMitophagymTOR signaling

Identifiers

PMID42304162
PMCPMC13272109

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.