Evidence map›Paper›PMID 42304134›Full record

ArticleCommunications biology2026

Neuroanatomical and behavioral characterization of corticotropin-releasing factor-expressing lateral Habenula neurons in mice.

William J Flerlage, Shawn C Gouty, Emily H Thomas, Sarah C Simmons, Mumeko C Tsuda, Oana L Rujan, Regina C Armstrong, Catherine M Davis, Laxmi Iyer, Emily Petrus and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

William J Flerlage *Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Shawn C Gouty *Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Emily H Thomas *Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Sarah C SimmonsDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Mumeko C TsudaPreclinical Behavior and Modeling Core, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Oana L RujanDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Regina C ArmstrongDepartment of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Catherine M DavisDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Laxmi IyerHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.ORCID 0000-0001-9218-4481
Emily PetrusDepartment of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Brian M CoxDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.ORCID 0000-0002-5000-2384
T John WuDepartment of Gynecologic Surgery and Obstetrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Fereshteh S NugentDepartment of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. fereshteh.nugent@usuhs.edu.ORCID 0000-0002-8840-6923

Funding

Intrinsic CRF signaling within the lateral habenulaR21MH132136 · NIMH · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI NUGENT, FERESHTEH S · 2023 to 2024
$418k
NIMH NIH HHS R21 MH132136U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R21 MH132136
6 · The paper itself

Abstract

The lateral habenula (LHb) is a critical hub for stress-related behaviors, yet the sources of its corticotropin-releasing factor (CRF) inputs remain poorly defined. Using high-resolution imaging, RNAscope, and viral tracing, we identified a novel, intrinsic population of CRF-expressing LHb neurons (LHb

Indexed as

Behavior, AnimalCorticotropin-Releasing HormoneHabenulaNeuronsAnimalsFemaleMaleMiceOptogeneticsSex CharacteristicsVesicular Glutamate Transport Protein 2Corticotropin-Releasing HormoneVesicular Glutamate Transport Protein 2

Identifiers

PMID42304134
PMCPMC13631236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.