Evidence map›Paper›PMID 42304100›Full record

ArticleNature immunology2026

Functional and dysfunctional T regulatory cell states in human tissues in RA and other autoimmune arthritic diseases.

Byunghee Koh, Shani T Gal Oz, Ryota Sato, Hung N Nguyen, Garrett Dunlap, Christopher Mahony, Chrissy Bolton, Accelerating Medicines Partnership (AMP) RA/SLE Network, Lucy R Wedderburn, Adam P Croft and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Byunghee Koh *Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. bhkoh.research@gmail.com.ORCID http://orcid.org/0000-0003-3554-4449
Shani T Gal Oz *Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7775-2006
Ryota SatoDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0009-0000-7681-3794
Hung N NguyenDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Garrett DunlapDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2627-0506
Christopher MahonyRheumatology Research Group, Department of Inflammation and Ageing, College of Medicine & Health, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0003-4487-2540
Chrissy BoltonRheumatology Research Group, Department of Inflammation and Ageing, College of Medicine & Health, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0003-0240-3244
Accelerating Medicines Partnership (AMP) RA/SLE Network
Lucy R WedderburnInfection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID http://orcid.org/0000-0002-7495-1429
Adam P CroftRheumatology Research Group, Department of Inflammation and Ageing, College of Medicine & Health, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0002-9487-0511
Laura DonlinWeill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-1428-090X
Melanie H SmithWeill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-2464-8429
Soumya RaychaudhuriDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1901-8265
Ilya KorsunskyDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Deepak A RaoDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9672-7746
Michael B BrennerDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. mbrenner@bwh.harvard.edu.ORCID http://orcid.org/0000-0001-6202-8445

Funding

Role of fibroblastic stromal cells and notch signaling in tissue inflammation in RA and SLEP01AI148102 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Betty Diamond · 2021 to 2026
$17.3M
Joint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4M
Integrative analysis of high dimensional tissue molecular data to define key biological systems in autoimmune diseases (SBC)UC2AR081023 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Soumya Raychaudhuri · 2022 to 2026
$4.8M
Predicting the impact of genetic variants, genes and pathways on human DiseaseU01HG012009 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ALKES L PRICE, Soumya Raychaudhuri · 2021 to 2026
$4.2M
Regulation of T helper cell functions by aryl hydrocarbon receptorR01AR078769 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI RAO, DEEPAK ANGARA · 2021 to 2025
$1.9M
U.S. Department of Health & Human Services | National Institutes of Health (NIH) 5K01AR078355U.S. Department of Health & Human Services | National Institutes of Health (NIH) P01AI148102U.S. Department of Health & Human Services | National Institutes of Health (NIH) P30AR070253U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AR078769U.S. Department of Health & Human Services | National Institutes of Health (NIH) U01HG012009U.S. Department of Health & Human Services | National Institutes of Health (NIH) UC2AR081023
6 · The paper itself

Abstract

Regulatory T cells (T

Indexed as

Arthritis, JuvenileArthritis, RheumatoidAutoimmune DiseasesT-Lymphocytes, RegulatoryAdultFemaleFibroblastsForkhead Transcription FactorsHumansInterleukin-2 Receptor alpha SubunitMacrophagesMaleReceptors, Tumor Necrosis Factor, Type IISynovial MembraneTumor Necrosis Factor-alphaForkhead Transcription FactorsFOXP3 protein, humanInterleukin-2 Receptor alpha SubunitReceptors, Tumor Necrosis Factor, Type IITumor Necrosis Factor-alpha

Identifiers

PMID42304100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.