ArticleScientific reports2026
Long-term occupational exposure to volatile organic compounds and progressive pulmonary function decline: a 5-year cohort study in the printing industry.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The printing industry involves continuous exposure to volatile organic compounds (VOCs), potentially leading to pulmonary impairments. This study aimed to evaluate long-term pulmonary impairments among printing workers over a five-year period. A five-year retrospective cohort study (2020-2024) was conducted involving 87 operational printing workers (exposed group) and 86 administrative staff members (unexposed group). Occupational exposure to VOCs (benzene, toluene, ethylbenzene, xylene, isopropyl alcohol, ethyl acetate, ethanol) was assessed using NIOSH-based air sampling and GC-FID analysis. Pulmonary function was measured annually using standardized spirometry according to American Thoracic Society (ATS) guidelines. Respiratory symptoms were evaluated with the ATS questionnaire. Groups were comparable in demographics except working hours (p < 0.05). A significant upward trend in VOCs concentrations-particularly toluene, xylene, and isopropanol-was observed throughout the follow-up period (p < 0.05). Exposed workers showed declines in FEV
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