Evidence map›Paper›PMID 42304062›Full record

ArticleScientific reports2026

Atomistic insights into the magnetic-field modulation of the [Formula: see text] adenosine receptor.

Carmen Pisano, Federico Del Signore, Paolo Marracino, Ilaria Pappa, Davide Cocco, Elena Della Valle, Simona Salati, Ruggero Cadossi, Micaela Liberti, Francesca Apollonio

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carmen PisanoDepartment of Information Engineering, Electronics and Telecommunications (DIET), Sapienza University of Rome, Rome, Italy.
Federico Del SignoreDepartment of Information Engineering, Electronics and Telecommunications (DIET), Sapienza University of Rome, Rome, Italy.
Paolo MarracinoRise Technology S.r.l., Rome, Italy.
Ilaria PappaDepartment of Information Engineering, Electronics and Telecommunications (DIET), Sapienza University of Rome, Rome, Italy.
Davide CoccoDepartment of Information Engineering, Electronics and Telecommunications (DIET), Sapienza University of Rome, Rome, Italy.
Elena Della ValleDepartment of Information Engineering, Electronics and Telecommunications (DIET), Sapienza University of Rome, Rome, Italy.
Simona SalatiMedical Division, IGEA, Carpi, Italy.
Ruggero CadossiMedical Division, IGEA, Carpi, Italy.
Micaela LibertiDepartment of Information Engineering, Electronics and Telecommunications (DIET), Sapienza University of Rome, Rome, Italy.
Francesca ApollonioDepartment of Information Engineering, Electronics and Telecommunications (DIET), Sapienza University of Rome, Rome, Italy. francesca.apollonio@uniroma1.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulsed electromagnetic fields (PEMFs) are increasingly used in clinical settings for the treatment of inflammatory and degenerative conditions. Among their molecular targets, [Formula: see text] adenosine receptors ([Formula: see text]) show increased receptor density on the cell membrane upon PEMF exposure, yet the underlying physical mechanism remains uncertain. In this study, atomistic molecular dynamics simulations were used to investigate how an external static magnetic field, used as a simplified representation of the quasi-static magnetic component of PEMF exposure, influences the structure and electrostatics of the [Formula: see text]. Our simulations revealed that the field predominantly affects the receptor's extracellular region, resulting in a transition from a closed to a more open conformation of the ligand-entry region. This structural rearrangement was accompanied by widening and increased hydration of the extracellular entrance, indicating enhanced accessibility of the orthosteric binding site. At residue level, Glu169, Ala265, and Pro266 exhibited pronounced dipole reorientation, indicating localized electrostatic adaptation consistent with the structural response. Together, these findings provide an atomistic insight into how magnetic perturbations can influence [Formula: see text] extracellular dynamics and offer a mechanistic framework compatible with experimental observations of altered [Formula: see text] function under PEMF exposure.

Indexed as

Magnetic FieldsReceptors, Purinergic P1Binding SitesElectromagnetic FieldsHumansLigandsMolecular Dynamics SimulationProtein ConformationStatic ElectricityLigandsReceptors, Purinergic P1[Formula: see text] adenosine receptorGPCRMagnetic fieldMolecular dynamics simulationsPulsed electromagnetic fields (PEMFs)

Identifiers

PMID42304062
PMCPMC13534643

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