Evidence map›Paper›PMID 42304054›Full record

ArticleScientific reports2026

Long-term burden of heart failure: a population-based cohort study on mortality and rehospitalizations.

Loreto Lancia, Angelo Dante, Valeria Caponnetto, Cristina Petrucci, Vittorio Masotta, Ilaria Paoli, Gianluca Azzellino, Leondino Mammarella, Silvio Romano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Loreto LanciaDepartment of Life, Health and Environmental Sciences, University of L'Aquila, Rita Levi Montalcini Building, Via Giuseppe Petrini, L'Aquila, 67100, Italy.
Angelo DanteDepartment of Life, Health and Environmental Sciences, University of L'Aquila, Rita Levi Montalcini Building, Via Giuseppe Petrini, L'Aquila, 67100, Italy.
Valeria CaponnettoDepartment of Life, Health and Environmental Sciences, University of L'Aquila, Rita Levi Montalcini Building, Via Giuseppe Petrini, L'Aquila, 67100, Italy. valeria.caponnetto@univaq.it.ORCID 0000-0003-4573-6110
Cristina PetrucciDepartment of Life, Health and Environmental Sciences, University of L'Aquila, Rita Levi Montalcini Building, Via Giuseppe Petrini, L'Aquila, 67100, Italy.
Vittorio MasottaDepartment of Life, Health and Environmental Sciences, University of L'Aquila, Rita Levi Montalcini Building, Via Giuseppe Petrini, L'Aquila, 67100, Italy.
Ilaria PaoliDepartment of Life, Health and Environmental Sciences, University of L'Aquila, Rita Levi Montalcini Building, Via Giuseppe Petrini, L'Aquila, 67100, Italy.
Gianluca AzzellinoDepartment of Life, Health and Environmental Sciences, University of L'Aquila, Rita Levi Montalcini Building, Via Giuseppe Petrini, L'Aquila, 67100, Italy.
Leondino MammarellaHealth Information Flows and Statistics Service, Epidemiological Observator, and Health Quality and Audit Service, ASL 1 Abruzzo, Avezzano-Sulmona-L'Aquila, Via Avezzano 11/C, L'Aquila, 67100, Italy.
Silvio RomanoDepartment of Life, Health and Environmental Sciences, University of L'Aquila, Rita Levi Montalcini Building, Via Giuseppe Petrini, L'Aquila, 67100, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure (HF) is a prevalent, progressive syndrome, and a leading cause of hospitalization, mortality, and healthcare expenditure worldwide, especially among older adults. This study aimed to assess the long-term burden of mortality, rehospitalizations and their composite among HF patients and to identify independent predictors of these outcomes. A population-based retrospective cohort study was conducted across all hospitals in the province of L'Aquila, Italy, including all residents discharged alive after an index HF hospitalization between 1 January 2014 and 31 December 2022, with follow-up through 31 December 2023. Kaplan-Meier analysis estimated event rates at 30 days, 90 days, 1 year, 5 years and 9 years. Predictors of the 5-year composite outcome (death or rehospitalization) and rehospitalization frequency were analyzed using multivariable Cox regression and negative binomial models. A total of 5,883 patients were included. By 5 years, 69.4% had experienced the composite outcome, increasing to 85.4% by 9 years. Nearly half of the rehospitalizations occurred in the first year. Older age, male sex, longer initial hospital stay, and earlier discharge year were associated with poorer outcomes. HF poses a long-term burden, highlighting the need for ongoing care, in which nurses are central to improve outcomes and care quality.

Indexed as

Heart FailurePatient ReadmissionAgedAged, 80 and overFemaleHospitalizationHumansItalyKaplan-Meier EstimateMaleRetrospective StudiesHeart failureLong-term outcomesMortalityNursing carePopulation-based studyRehospitalization

Identifiers

PMID42304054
PMCPMC13538688

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.