ArticleScientific reports2026
Quantitative relationship between cycle threshold values and infectious influenza virus in patient nasopharyngeal samples.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Real-time reverse transcription polymerase chain reaction (rRT-PCR) is nowadays commonly used to diagnose viral infections. This assay provides cycle threshold (Ct) values, which inversely correlate with viral load but do not directly indicate infectivity. The relationship between Ct values and infectivity remains unclear. As a first step, we assessed this relationship in nasopharyngeal samples from 97 seasonal influenza A (IAV) and 95 influenza B (IBV) virus-rRT-PCR-positive patients. Samples were cultured, viral RNA was quantified using reverse transcriptase digital PCR, and antibody titers against hemagglutinin (HA) were evaluated. We found a robust inverse correlation between sample Ct value and infectious virus titer and virus cultures are consistently positive at Ct < 22 with a 10% positive culture probability near Ct 36, which corresponds to 5.37 × 10
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