Evidence map›Paper›PMID 42304029›Full record

ArticleScientific reports2026

Causal multi-fidelity surrogate forward and inverse models for ICF implosions.

Tyler E Maltba, Ben S Southworth, Jeffrey R Haack, Marc L Klasky

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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Tyler E MaltbaTheoretical Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA. tyler.maltba@lancium.com.
Ben S SouthworthTheoretical Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA. southworth@lanl.gov.
Jeffrey R HaackComputer, Computational, and Statistical Sciences Division, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA.
Marc L KlaskyTheoretical Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA. mklasky@lanl.gov.

Funding

LANL Laboratory Directed Research and Development 20230068DR
6 · The paper itself

Abstract

Continued progress in inertial confinement fusion (ICF) requires solving inverse problems relating experimental observations to simulation input parameters, followed by design optimization. However, such high-dimensional dynamic PDE-constrained optimization problems are extremely challenging or even intractable. It has been recently shown that inverse problems can be solved by only considering certain robust features. Here we consider the ICF capsule's deuterium-tritium (DT) interface, and construct a causal, dynamic, multifidelity reduced-order surrogate that maps from a time-dependent radiation temperature drive to the interface's radius and velocity dynamics. The surrogate targets an ODE embedding of DT interface dynamics, and is constructed by learning a controller for a base analytical model using low- and high-fidelity simulation training data with respect to radiation energy group structure. After demonstrating excellent accuracy of the surrogate interface model, we use machine learning (ML) models with surrogate-generated data to solve inverse problems optimizing radiation temperature drive to reproduce observed interface dynamics. For sparse snapshots in time, the ML model further characterizes the most informative times at which to sample dynamics. Altogether we demonstrate how operator learning, causal architectures, and physical inductive bias can be integrated to accelerate discovery, design, and diagnostics in high-energy-density systems.

Identifiers

PMID42304029
PMCPMC13534444

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.