ArticleNature communications2026
Structural basis and immunogenic efficacy of porcine circovirus type 3 virus-like particle.
Jinfu Su, Xiaodan Tong, Yanan Jiang, Yu Li, He Yan, Yan Liu, Yanwei Wang, Xiaorui Su, Zhe Sun, Mengyue Wang and 6 more
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In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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16 authors.
Jinfu Su *State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, School of Life Sciences, Xiamen University, Xiamen, China.ORCID http://orcid.org/0009-0004-9308-3630 Xiaodan Tong *National Research Center for Veterinary Medicine, Luoyang, China.
Yanan Jiang *State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, School of Life Sciences, Xiamen University, Xiamen, China.
Yu LiState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, School of Life Sciences, Xiamen University, Xiamen, China.ORCID http://orcid.org/0009-0008-5392-8917 He YanNational Research Center for Veterinary Medicine, Luoyang, China.
Yan LiuNational Research Center for Veterinary Medicine, Luoyang, China.
Yanwei WangNational Research Center for Veterinary Medicine, Luoyang, China.
Xiaorui SuNational Research Center for Veterinary Medicine, Luoyang, China.
Zhe SunNational Research Center for Veterinary Medicine, Luoyang, China.
Mengyue WangNational Research Center for Veterinary Medicine, Luoyang, China.
Ningshao XiaState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, School of Life Sciences, Xiamen University, Xiamen, China.ORCID http://orcid.org/0000-0003-0179-5266 Mihnea BostinaDepartment of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
Shaowei LiState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, School of Life Sciences, Xiamen University, Xiamen, China. shaowei@xmu.edu.cn.ORCID http://orcid.org/0000-0002-3374-1038 Wenqiang PangNational Research Center for Veterinary Medicine, Luoyang, China. pangwenqiang@pulike.com.cn.
Qingbing ZhengState Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, School of Life Sciences, Xiamen University, Xiamen, China. qbzheng@xmu.edu.cn.ORCID http://orcid.org/0000-0002-7516-9965 Kegong TianNational Research Center for Veterinary Medicine, Luoyang, China. vetvac@126.com.
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Porcine circovirus type 3 (PCV3) is an emerging swine pathogen associated with reproductive failure and systemic inflammation, but vaccines for related PCV2 provide limited cross-protection. Here, we determine high-resolution cryo-EM structures of PCV3 capsid protein assembled into virus-like particles (VLPs) and of PCV3 VLPs bound to the PCV3-specific antibody 2B5. The structures reveal differences from PCV2 in surface loops and define a conserved 2B5 epitope mainly involving the BC, EF and HI loops, providing a structural basis for PCV3-specific recognition. PCV3 VLPs induce sustained antibody responses in mice and pigs. In a pig challenge model, VLP immunization prevents viremia and viral replication in lungs and lymph nodes, as measured by quantitative PCR and in situ hybridization, with protection maintained for at least five months after boosting. These findings support PCV3 VLPs as a vaccine candidate against PCV3 infection.
Indexed as
Circoviridae InfectionsCircovirusSwine DiseasesVaccines, Virus-Like ParticleViral VaccinesAnimalsAntibodies, ViralCapsid ProteinsCryoelectron MicroscopyEpitopesFemaleMiceSwineAntibodies, ViralCapsid ProteinsEpitopesVaccines, Virus-Like ParticleViral Vaccines
Identifiers
PMID42303972
PMCPMC13434755
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LicenceCC BY-NC-ND
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