ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
Atrial natriuretic peptide can be biomarker for predicting atrial fibrillation in embolic stroke of undetermined source.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAtrial fibrillation (AF) drives cardioembolic stroke, yet paroxysmal AF (PAF) often escapes detection in embolic stroke of undetermined source (ESUS). We evaluated whether atrial natriuretic peptide (ANP) can identify latent PAF in ESUS, compared with brain natriuretic peptide (BNP).
methodsProspective single-center cohort of ESUS patients admitted within 24 h without admission AF. Admission ANP/BNP were assayed; PAF was screened by 14-day continuous ECG. Patients were grouped as PAF-detected or ESUS. Logistic regression (LAD, ANP, BNP) and ROC assessed diagnostic performance.
resultsOf 567 patients with cerebral infarction, 111 met the criteria for ESUS, and 64 were included after exclusions. PAF was detected in 30 patients, and 34 remained classified as ESUS. Baseline comparisons showed significant differences in age, ANP, BNP, and LAD. In multivariable logistic regression analysis, ANP was independently associated with PAF detection (p = 0.015), whereas BNP and LAD were not. ROC analysis showed an AUC of 0.901 (95% CI, 0.818-0.984) for ANP and 0.892 (95% CI, 0.811-0.973) for BNP, with no significant difference between them (p = 0.821). ANP demonstrated clinically useful performance with a cutoff value of 63.9 pg/mL (sensitivity 94.1%, specificity 83.3%).
conclusionsANP was identified as an independent predictor of PAF detection in patients with ESUS, with strong ROC performance. Given its atrial origin and very short half-life, ANP may serve as an atrium-specific biomarker reflecting acute atrial load, potentially enabling earlier identification of latent PAF in the acute phase.
Indexed as
Identifiers
42303893What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.