ArticleClinical and experimental nephrology2026
Distinct glomerular and tubulointerstitial injury pathways in infective endocarditis-associated glomerulonephritis: a case series.
Article in Clinical and experimental nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundInfective endocarditis-associated glomerulonephritis (IE-GN) causes acute kidney injury with unclear pathogenesis. Previous studies focused on glomerular lesions with limited understanding of tubulointerstitial involvement. We investigated clinicopathological characteristics of renal involvement in IE, focusing on distinct injury patterns in glomeruli and tubulointerstitium.
methodsWe conducted a retrospective case series of five male patients (age 46-74 years) with confirmed infective endocarditis (IE) who underwent kidney biopsy at Toranomon Hospital between January 1, 2001, and August 31, 2024. The diagnosis of IE was made based on the modified Duke criteria (2011).
resultsBlood cultures were positive for Streptococcus (n = 4) and Granulicatella (n = 1). Acute kidney injury was present in three patients with eGFR of 6.5-23.9 mL/min/1.73 m
conclusionsThis analysis of five cases suggests that IE-GN involves dual pathogenic pathways: immune complex-mediated glomerular injury and tubulointerstitial injury related to bacterial burden, with tubulointerstitial lesions more strongly associated with renal dysfunction.
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