Evidence map›Paper›PMID 42303860›Full record

ArticleBiological trace element research2026

Nickel(II) and Zinc(II) Binding to Tau Protein Fragments Containing Histidine and Cysteine.

Faareha Mazhar, Noémi Piskolti, Viktória Kovács, Katalin Várnagy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Faareha MazharDepartment of Inorganic and Analytical Chemistry, University of Debrecen, Debrecen, H-4032, Hungary.
Noémi PiskoltiDepartment of Inorganic and Analytical Chemistry, University of Debrecen, Debrecen, H-4032, Hungary.
Viktória KovácsDepartment of Inorganic and Analytical Chemistry, University of Debrecen, Debrecen, H-4032, Hungary.
Katalin VárnagyDepartment of Inorganic and Analytical Chemistry, University of Debrecen, Debrecen, H-4032, Hungary. varnagy.katalin@science.unideb.hu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tau protein plays a crutial role in stablizing the neuronal microtubules in the human brain, under normal physiological environment. This protein contains 12 histidines and 2 cysteines, which are typically the primary metal binding sites. As the metal ions may participate in tau protein aggregation processes and the development of taupathies, we characterized zinc(II) and nickel(II) complexes of tau fragments. The studied peptides were; single-His299 containing tau(292-301) (Ac-GSKDNIKHVP-NH

Indexed as

CysteineHistidineNickeltau ProteinsZincBinding SitesHumansProtein BindingCysteineHistidineNickeltau ProteinsZincComplexCysteineHistidineNickel(II)PotentiometryTau proteinUV-Vis and CD spectroscopy

Identifiers

PMID42303860
PMCPMC13437714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.