ArticleJournal of exposure science & environmental epidemiology2026
Long-term exposure to outdoor air pollutants and risk of pancreatic cancer in a large prospective U.S.-based cohort.
Article in Journal of exposure science & environmental epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
backgroundOutdoor air pollutants have been inconsistently associated with pancreatic cancer incidence and mortality.
objectiveWe investigated associations between outdoor fine particulate matter (PM
methodsWe estimated historical pollutant concentrations at enrollment (1995-1996) residences in the NIH-AARP Diet and Health Study (N = 486,431). We estimated hazard ratios and 95% confidence intervals (HR [CI]) for associations (continuous and categorical) with incident pancreatic cancer overall (N = 4999) and pancreatic ductal adenocarcinomas (PDAC; N = 4708) in models adjusted for lifestyle and sociodemographic factors.
resultsWe observed small, non-significant associations with pancreatic cancer overall (PM SIGNIFICANCE: Marginal associations between PM IMPACT: This study builds on a small prior literature of associations between air pollution and pancreatic cancer risk. Our analyses in a large U.S.-based cohort revealed small, positive, but non-statistically significant associations between PM
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