Evidence map›Paper›PMID 42303811›Full record

ArticleEMBO reports2026

Hemagglutinin double-mutation enhances binding of human-infecting avian influenza virus clade 2.3.4.4b H5Ny to human and SLe

Xiyue Jin, Pu Han, Yuxuan Wang, Haichen Wang, Chunge Zhang, Antonio Di Maio, Jin Yu, Tianjiao Hao, Yuhang Gu, Zeyu Zhang and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Xiyue Jin *CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Pu Han *CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Yuxuan WangSchool of Life Sciences, Hebei University, Baoding, Hebei, China.
Haichen WangSchool of Life Sciences, Hebei University, Baoding, Hebei, China.ORCID 0009-0002-2661-1347
Chunge ZhangCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Antonio Di MaioGlycosciences Laboratory, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.ORCID 0000-0002-2740-9098
Jin YuGlycosciences Laboratory, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.
Tianjiao HaoBeijing Life Science Academy, Beijing, China.
Yuhang GuCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Zeyu ZhangBeijing Life Science Academy, Beijing, China.
Wei ZhangCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Jianxun QiCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0002-9358-4732
Yuhai BiCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Xu ZhangBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing, China.
Lei SunDepartment of Pathology, Beijing Ditan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-0101-0695
Ningli WangBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing, China.
Yan LiuGlycosciences Laboratory, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK. yan.liu2@imperial.ac.uk.ORCID 0000-0002-2566-6867
Hao SongNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Key Laboratory of Viral Infectious Diseases, Beijing Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. songhao@im.ac.cn.ORCID 0000-0002-2811-0370
George F GaoCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. gaof@im.ac.cn.ORCID 0000-0002-3869-615X

Funding

the National Natural Science Foundation of China NSFC,92478001the Welcome Trust Biomedical Resource Grants WT099197/Z/12/Z,108430/Z/15/Z,218304/Z/19/Z
6 · The paper itself

Abstract

Clade 2.3.4.4b H5Ny highly pathogenic avian influenza viruses (HPAIVs) continue to circulate worldwide, posing zoonotic threats, especially with recent cattle outbreaks. The mechanisms by which these viruses adapt to mammalian hosts while maintaining a broad avian tropism remain poorly understood. Here, we demonstrate that two naturally occurring mutations (K222Q and S227R) in the hemagglutinin (HA) of a human-infecting H5N8 strain, first identified in 2020, enhance binding affinity for both α2-6-linked and Sialyl Lewis

Indexed as

Hemagglutinin Glycoproteins, Influenza VirusInfluenza A virusInfluenza, HumanMutationOligosaccharidesReceptors, VirusAnimalsDucksHumansInfluenza in BirdsProtein BindingVirus AttachmentHemagglutinin Glycoproteins, Influenza VirusOligosaccharidesReceptors, Virus

Identifiers

PMID42303811
PMCPMC13400655

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.