ReviewEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2026
Current research on the role of HIF in intervertebral disc degeneration.
Review in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
purposeLow back pain affects a large population globally, and intervertebral disc degeneration (IVDD) is one of its major causes. This review aims to summarize the roles and molecular mechanisms of hypoxia-inducible factors (HIFs) in IVDD progression, and provide theoretical support for developing precise treatment strategies for IVDD.
methodsWe systematically retrieved, sorted and analyzed recent peer-reviewed studies concerning the association between HIF family members and IVDD.
resultsIVDD involves complex pathological changes including hypoxic microenvironment imbalance, inflammatory responses, extracellular matrix (ECM) dysfunction and altered autophagy. HIFs, key oxygen-sensing regulators, exert bidirectional effects on IVDD: they can either alleviate or accelerate disc degeneration under different conditions.
conclusionHIFs play a central regulatory role in IVDD. Targeting HIF-related pathways holds great potential for clinical translation, and further research is still required to clarify unresolved mechanisms.
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