A novel eco-friendly HPTLC approach for the simultaneous determination of erdosteine, ibuprofen and pseudoephedrine pharmaceutical combination.

Feda A H Elgammal, Maram G Hafez, Hadeel A Khalil, Dina A Gawad, Tarek S Belal

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Feda A H ElgammalPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Elmessalah, Alexandria, 21521, Egypt.

Maram G HafezPostgraduate Student, Faculty of Pharmacy, University of Alexandria, Elmessalah, Alexandria, 21521, Egypt.

Hadeel A KhalilPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Elmessalah, Alexandria, 21521, Egypt.

Dina A GawadPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Elmessalah, Alexandria, 21521, Egypt.

Tarek S BelalPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Elmessalah, Alexandria, 21521, Egypt. tarek.belal@alexu.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper introduces the first validated and ecofriendly high-performance thin-layer chromatographic (HPTLC) method for the simultaneous determination of erdosteine (ERD), ibuprofen (IBU), and pseudoephedrine (PSE) pharmaceutical combination. This drug combination aids in treating symptoms associated with upper respiratory tract infections (URTIs) by providing mucolytic, analgesic, anti-inflammatory, and decongestant effects within a single therapeutic regimen. The chromatographic separation was effectively achieved on a silica gel 60F

Indexed as

IbuprofenPseudoephedrineThioglycolatesThiophenesChromatography, Thin LayerDrug CombinationsReproducibility of ResultsDrug CombinationserdosteineIbuprofenPseudoephedrineThioglycolatesThiophenesErdosteineGreenness assessmentHPTLCIbuprofenPseudoephedrineSustainability assessment

Identifiers

PMID42303778

DOI10.1038/s41598-026-57106-z

PMCPMC13273069

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.